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Fibro-Osseous Lesions of the Craniofacial Skeleton: An Update

  • Update in Gnathic Pathology. Guest Editors: Angela Chi, DMD and John Wright, DDS
  • Published:
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Abstract

Benign fibro-osseous lesions of the craniofacial skeleton (BFOL) are a variant group of intraosseous disease processes that share similar microscopic features characterized by hypercellular fibroblastic stroma containing various combinations of bone or cementum-like tissue and other calcified structures [1–6]. Whereas some are diagnosable histologically, most require a combined assessment of clinical, microscopic and radiologic features. Some BFOL of the craniofacial complex are unique to that location whereas others are encountered in bones from other regions. Reactive, neoplastic, developmental and dysplastic pathologic processes are included under the rubric of BFOL and treatment varies from disease to disease. This review will discuss the clinical, microscopic and radiologic aspects of the more important types of BFOL of the craniofacial complex with updated information on underlying genetic and molecular pathogenic mechanisms of disease. Four main groups of BFOLs will be addressed.

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Acknowledgments

The national and international community of Oral and Head and Neck pathologists are particularly grateful for Lewis Roy Eversole role in founding this Journal and for acting as its first co-Editor-In-Chief.

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  1. Department of Pathology and Immunology, Washington University School of Medicine, 660 Euclid Ave., Campus Box 8118, St. Louis, MO, USA

    Samir K. El-Mofty

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Correspondence to Samir K. El-Mofty.

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This article is dedicated to Lewis Roy Eversole DDS, MSD, MA: a generous teacher, dedicated scholar and esteemed colleague and friend. His vast and seminal contributions to the field of Oral and Maxillofacial Pathology and particularly to the fascinating subject of fibro-osseous lesions of the maxillofacial skeleton are acknowledged.

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El-Mofty, S.K. Fibro-Osseous Lesions of the Craniofacial Skeleton: An Update. Head and Neck Pathol 8, 432–444 (2014). https://doi.org/10.1007/s12105-014-0590-0

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