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Epithelial Salivary Gland Tumors in Two Distant Geographical Locations, Finland (Helsinki and Oulu) and Israel (Tel Aviv): A 10-Year Retrospective Comparative Study of 2,218 Cases

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Abstract

Salivary gland tumors (SGTs) of epithelial origin are relatively rare, and worldwide reports show considerable variations in their epidemiology. The aim of this study was to examine, for the first time, the records of SGTs from two very distant geographical locations, Finland (two medical centers) and Israel (one medical center) between 1999 and 2008, based exclusively on the 2005 WHO classification of head and neck tumors, and to compare those data to the other available (single-center) studies that used the same classification. A total of 2,218 benign and malignant tumors diagnosed in the three centers were analyzed. Differences in classification of the tumors were found between the two geographical locations as well as between the two centers from Finland. There was a higher ratio of benign-to-malignant SGTs in the Finnish centers (5.4:1 and 7:1) compared to the Israeli center (2:1), a higher frequency of tumors of minor salivary glands in the Israeli center (34%) than in the Finnish centers (4 and 11%), and a higher frequency of malignant SGTs in the minor salivary glands in Israel (64.5%) than in Finland (10.9 and 27%). The diversity of these multicenter data are compatible with reports from different parts of the world. We conclude that conducting epidemiologic surveys based on the latest WHO classification provides clinicopathologic correlations on SGTs that seem to be characteristic even in small geographical regions.

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References

  1. Barnes L, Eveson JW, Reichert P, et al. World health classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005.

    Google Scholar 

  2. Ellis GL, Auclair PL. Atlas of tumor pathology. Tumors of the salivary glands. Washington DC: AFIP; 1995.

    Google Scholar 

  3. Seifert G, Sobin LH. Histological typing of salivary glands tumours. World Health Organization, International histological classification of tumours. 2nd ed. New York: Springer; 1991.

    Book  Google Scholar 

  4. Seethala RR, Barnes EL, Hunt JL. Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol. 2007;31:44–57.

    Article  PubMed  Google Scholar 

  5. Skalova A, Vanecek T, Sima R, et al. Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 2010;34:599–608.

    PubMed  Google Scholar 

  6. Skalova A, Sima R, Kaspirkova-Nemcova J, et al. Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. Am J Surg Pathol. 2011;35:1168–76.

    Article  PubMed  Google Scholar 

  7. Buchner A, Merrell PW, Carpenter WM. Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from northern California and comparison to reports from other parts of the world. J Oral Pathol Med. 2007;36:207–14.

    Article  PubMed  Google Scholar 

  8. Yaor MA. The pattern of presentation of salivary gland tumors in Africa: a review of published reports. Ear Nose Throat J. 2010;89:E17–21.

    PubMed  Google Scholar 

  9. Tilakaratne WM, Jayasooriya PR, Tennakoon TM, et al. Epithelial salivary tumors in Sri Lanka: a retrospective study of 713 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:90–8.

    Article  PubMed  Google Scholar 

  10. Eveson JW, Cawson RA. Salivary gland tumours. A review of 2410 cases with particular reference to histological types, site, age and sex distribution. J Pathol. 1985;146:51–8.

    Article  PubMed  CAS  Google Scholar 

  11. Spiro RH. Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg. 1986;8:177–84.

    Article  PubMed  CAS  Google Scholar 

  12. Pinkston JA, Cole P. Incidence rates of salivary gland tumors: results from a population-based study. Otolaryngol Head Neck Surg. 1999;120:834–40.

    Article  PubMed  CAS  Google Scholar 

  13. de Oliveira FA, Duarte EC, Taveira CT, et al. Salivary gland tumor: a review of 599 cases in a Brazilian population. Head Neck Pathol. 2009;3:271–5.

    Article  PubMed  Google Scholar 

  14. Al-Khateeb TH, Ababneh KT. Salivary tumors in north Jordanians: a descriptive study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:e53–9.

    Article  PubMed  Google Scholar 

  15. Kolude B, Lawoyin JO, Akang EE. Salivary gland neoplasms: a 21 year review of cases seen at University College Hospital, Ibadan. Afr J Med Med Sci. 2001;30:95–8.

    PubMed  CAS  Google Scholar 

  16. Luukkaa H, Klemi P, Leivo I, et al. Salivary gland cancer in Finland 1991–96: an evaluation of 237 cases. Acta Otolaryngol. 2005;125:207–14.

    Article  PubMed  Google Scholar 

  17. Koivunen P, Suutala L, Schorsch I, et al. Malignant epithelial salivary gland tumors in northern Finland: incidence and clinical characteristics. Eur Arch Otorhinolaryngol. 2002;259:146–9.

    Article  PubMed  Google Scholar 

  18. Finnish Cancer Registry. Cancer statistics: age-adjusted incidence rates of cancer per 100,000 person-years in 1961–2007, by primary site and period, www.cancerregistry.fi/eng/statistics.AID122.html (last accessed 25/10/2010).

  19. Nagler RM, Laufer D. Tumors of the major and minor salivary glands: review of 25 years of experience. Anticancer Res. 1997;17:701–7.

    PubMed  CAS  Google Scholar 

  20. Czerninski R, Zini A, Sgan-Cohen HD. Risk of parotid malignant tumors in Israel (1970–2006). Epidemiology. 2011;22:130–1.

    Article  PubMed  Google Scholar 

  21. Shishegar M, Ashraf MJ, Azarpira N et al. Salivary gland tumors in maxillofacial region: a retrospective study of 130 cases in a southern Iranian population. Pathol Res Int. 2011; doi:10.4061/2011/934350.

  22. Kara MI, Goze F, Ezirganh S, et al. Neoplasms of the salivary glands in a Turkish adult population. Med Oral Patol Oral Cir Bucal. 2010;15:e880–5.

    Article  PubMed  Google Scholar 

  23. Jones AV, Craig GT, Speight PM, et al. The range and demographics of salivary gland tumours diagnosed in a UK population. Oral Oncol. 2008;44:407–17.

    Article  PubMed  CAS  Google Scholar 

  24. Tian Z, Li L, Wang L, et al. Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg. 2010;39:235–42.

    Article  PubMed  CAS  Google Scholar 

  25. Cardis E, Richardson L, Deltour I, et al. The INTERPHONE study: design, epidemiological methods, and description of the study population. Eur J Epidemiol. 2007;22:647–64.

    Article  PubMed  Google Scholar 

  26. Sadetzki S, Chetrit A, Jarus-Hakak A, et al. Cellular phone use and risk of benign and malignant parotid gland tumors–a nationwide case-control study. Am J Epidemiol. 2008;167:457–67.

    Article  PubMed  Google Scholar 

  27. Auvinen A, Hietanen M, Luukkonen R, et al. Brain tumors and salivary gland cancers among cellular telephone users. Epidemiology. 2002;13:356–9.

    Article  PubMed  Google Scholar 

  28. Renehan A, Gleave EN, Hancock BD, et al. Long-term follow-up of over 1000 patients with salivary gland tumours treated in a single centre. Br J Surg. 1996;83:1750–4.

    Article  PubMed  CAS  Google Scholar 

  29. Dayan D, Vered M, Paz T, et al. Aging of human palatal salivary glands: a histomorphometric study. Exp Gerontol. 2000;35:85–93.

    Article  PubMed  CAS  Google Scholar 

  30. Vered M, Buchner A, Haimovici E, et al. Focal lymphocytic infiltration in aging human palatal salivary glands: a comparative study with labial salivary glands. J Oral Pathol Med. 2001;30:7–11.

    Article  PubMed  CAS  Google Scholar 

  31. Mantovani A, Allavena P, Sica A, et al. Cancer-related inflammation. Nature. 2008;454:436–44.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

Esther Eshkol is thanked for editorial assistance.

Conflict of Interest

The authors declare that they have no conflict of interest.

Author information

Author notes

  1. Ilmo Leivo

    Present address: Department of Pathology, University of Turku, Turku, Finland

Authors and Affiliations

  1. Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland

    Ibrahim O. Bello & Tuula Salo

  2. Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland

    Ibrahim O. Bello, Alhadi Almangoush & Ilmo Leivo

  3. Department of Pathology, Oulu University Hospital, Oulu, Finland

    Tuula Salo

  4. Institute of Dentistry, University of Helsinki, Helsinki, Finland

    Tuula Salo

  5. Department of Oral Pathology and Oral Medicine, School of Dentistry, Tel Aviv University, 69978, Tel Aviv, Israel

    Dan Dayan, Anna Schnaiderman-Shapiro & Marilena Vered

  6. Community Dental Office, Kemi, Finland

    Elisa Tervahauta

  7. Institute of Pathology, The Chaim Sheba Medical Center, Tel Hashomer, Israel

    Iris Barshack & Marilena Vered

  8. Department of Pathology, Turku University Hospital, Turku, Finland

    Ilmo Leivo

Authors
  1. Ibrahim O. Bello
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  2. Tuula Salo
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  8. Ilmo Leivo
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  9. Marilena Vered
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Corresponding author

Correspondence to Marilena Vered.

Additional information

The authors Tuula Salo and Marilena Vered contributed equally.

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Bello, I.O., Salo, T., Dayan, D. et al. Epithelial Salivary Gland Tumors in Two Distant Geographical Locations, Finland (Helsinki and Oulu) and Israel (Tel Aviv): A 10-Year Retrospective Comparative Study of 2,218 Cases. Head and Neck Pathol 6, 224–231 (2012). https://doi.org/10.1007/s12105-011-0316-5

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  • DOI: https://doi.org/10.1007/s12105-011-0316-5

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