Abstract
We present the first case (male, 35 years old) of a mammary analogue secretory carcinoma occurring in a submandibular gland and document findings on fine needle aspiration cytology. On histology, the tumor displayed characteristic features: circumscribed nodules composed of bland, pink to light red neoplastic cells with low proliferative/mitotic activity arranged in tubular, vaguely cribriform, and microcystic structures containing Periodic acid Schiff-positive, diastase-resistant secretory material. Immunohistochemistry showed strong and diffuse positivity for cytokeratin 7, S100 protein, and vimentin, as well as moderate to strong immunoreactivity for c-kit in the majority of tumor cells. A rearrangement of the ETV6 gene on fluorescence in situ hybridization was documented. The patient underwent an ipsilateral selective (levels I–IV) neck dissection which showed metastasis in 3 out of 36 lymph nodes (levels 1–3). Adjuvant radiotherapy was administered. No local recurrence or metastatic disease has been detected during a follow up period of 28 months.
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We thank Tomas Vanecek, PhD, for skillful assistance with the molecular genetic study.
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Petersson, F., Lian, D., Chau, Y.P. et al. Mammary Analogue Secretory Carcinoma: The First Submandibular Case Reported Including Findings on Fine Needle Aspiration Cytology. Head and Neck Pathol 6, 135–139 (2012). https://doi.org/10.1007/s12105-011-0283-x
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DOI: https://doi.org/10.1007/s12105-011-0283-x