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A Review of NUT Midline Carcinoma

  • Proceedings of the NASHNP Companion Meeting, February, 2011, San Antonio, TX
  • Published:
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Abstract

Nut midline carcinomas are uncommon carcinomas characterized by chromosomal rearrangements that involve the gene encoding the nuclear protein of the testis (NUT). This article reviews the clinicopathologic features of these malignancies. Ancillary testing is discussed as well as the pathologic differential diagnosis.

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References

  1. Kees UR, Mulcahy MT. Willoughby ML: intrathoracic carcinoma in an 11-year-old girl showing a translocation t(15;19). Am J Pediatr Hematol Oncol. 1991;13:459–64.

    Article  CAS  PubMed  Google Scholar 

  2. Kubonishi I, Takehara N, Iwata J, Sonobe H, Ohtsuki Y, Abe T. Miyoshi I: novel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinoma. Cancer Res. 1991;51:3327–8.

    CAS  PubMed  Google Scholar 

  3. Dang TP, Gazdar AF, Virmani AK, Sepetavec T, Hande KR, Minna JD, Roberts JR. Carbone DP: chromosome 19 translocation, overexpression of Notch3, and human lung cancer. J Natl Cancer Inst. 2000;92:1355–7.

    Article  CAS  PubMed  Google Scholar 

  4. Engleson J, Soller M, Panagopoulos I, Dahlen A, Dictor M, Jerkeman M. Midline carcinoma with t(15;19) and BRD4-NUT fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy. BMC Cancer. 2006;6:69.

    Article  PubMed  Google Scholar 

  5. French CA. Demystified molecular pathology of NUT midline carcinomas. J Clin Pathol. 2008;63:492–6.

    Google Scholar 

  6. French CA, Kutok JL, Faquin WC, Toretsky JA, Antonescu CR, Griffin CA, Nose V, Vargas SO, Moschovi M, Tzortzatou-Stathopoulou F, Miyoshi I, Perez-Atayde AR, Aster JC. Fletcher JA: midline carcinoma of children and young adults with NUT rearrangement. J Clin Oncol. 2004;22:4135–9.

    Article  CAS  PubMed  Google Scholar 

  7. French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR. Fletcher JA: BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001;159:1987–92.

    Article  CAS  PubMed  Google Scholar 

  8. French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR. Fletcher JA: BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003;63:304–7.

    CAS  PubMed  Google Scholar 

  9. French CA, Ramirez CL, Kolmakova J, Hickman TT, Cameron MJ, Thyne ME, Kutok JL, Toretsky JA, Tadavarthy AK, Kees UR, Fletcher JA. Aster JC: BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. Oncogene. 2008;27:2237–42.

    Article  CAS  PubMed  Google Scholar 

  10. Lee AC, Kwong YI, Fu KH, Chan GC, Ma L, Lau YL. Disseminated mediastinal carcinoma with chromosomal translocation (15;19). A distinctive clinicopathologic syndrome. Cancer. 1993;72:2273–6.

    Article  CAS  PubMed  Google Scholar 

  11. Mertens F, Wiebe T, Adlercreutz C, Mandahl N, French CA. Successful treatment of a child with t(15;19)-positive tumor. Pediatr Blood Cancer. 2007;49:1015–7.

    Google Scholar 

  12. Stelow EB, Bellizzi AM, Taneja K, Mills SE, Legallo RD, Kutok JL, Aster JC. French CA: NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract. Am J Surg Pathol. 2008;32:828–34.

    Article  PubMed  Google Scholar 

  13. Toretsky JA, Jenson J, Sun CC, Eskenazi AE, Campbell A, Hunger SP, Caires A, Frantz C, Hill JL. Stamberg J: translocation (11;15;19): a highly specific chromosome rearrangement associated with poorly differentiated thymic carcinoma in young patients. Am J Clin Oncol. 2003;26:300–6.

    Article  PubMed  Google Scholar 

  14. Vargas SO, French CA, Faul PN, Fletcher JA, Davis IJ, Dal Cin P. Perez-Atayde AR: upper respiratory tract carcinoma with chromosomal translocation 15;19: evidence for a distinct disease entity of young patients with a rapidly fatal course. Cancer. 2001;92:1195–203.

    Article  CAS  PubMed  Google Scholar 

  15. Stelow EB. French CA: carcinomas of the upper aerodigestive tract with rearrangement of the nuclear protein of the testis (NUT) gene (NUT midline carcinomas). Adv Anat Pathol. 2009;16:92–6.

    Article  CAS  PubMed  Google Scholar 

  16. den Bakker MA, Beverloo BH, van den Heuvel-Eibrink MM, Meeuwis CA, Tan LM, Johnson LA, French CA. van Leenders GJ: NUT midline carcinoma of the parotid gland with mesenchymal differentiation. Am J Surg Pathol. 2009;33:1253–8.

    Article  Google Scholar 

  17. Fujioka N, French CA, Cameron MJ. Kratzke RA: long-term survival of a patient with squamous cell carcinoma harboring NUT gene rearrangement. J Thorac Oncol. 2010;5:1704–5.

    Article  PubMed  Google Scholar 

  18. Hsieh MS, French CA, Liang CW, Hsiao CH: NUT midline carcinoma: case report and review of the literature. Int J Surg Pathol. 2009. doi:10.1177/1066896909353600.

  19. Nelson BA, Lee EY, French CA, Bauer DE. Vargas SO: BRD4-NUT carcinoma of the mediastinum in a pediatric patient: multidetector computed tomography imaging findings. J Thorac Imaging. 2010;25:W93–6.

    Article  PubMed  Google Scholar 

  20. Shehata B, Steelman CK, Abramowsky CR, Olson T, French C, Saxe D, Ricketts R, Katzenstein H: NUT midline carcinoma in a newborn with multiorgan disseminated tumor and a two-year-old with a pancreatic/hepatic primary. Pediatr Dev Pathol. 2009. doi:10.2350/09-10-0727-CR.1.

  21. Ziai J, French CA. Zambrano E: NUT gene rearrangement in a poorly-differentiated carcinoma of the submandibular gland. Head Neck Pathol. 2010;4:163–8.

    Article  PubMed  Google Scholar 

  22. Stelow EB, Mills SE. Squamous cell carcinoma variants of the upper aerodigestive tract. Am J Clin Pathol. 2005;124(Suppl):S96–109.

    PubMed  Google Scholar 

  23. Bellizzi AM, Bruzzi C, French CA. Stelow EB: the cytologic features of NUT midline carcinoma. Cancer Cytopathol. 2009;117:508–15.

    PubMed  Google Scholar 

  24. Haack H, Johnson LA, Fry CJ, Crosby K, Polakiewicz RD, Stelow EB, Hong SM, Schwartz BE, Cameron MJ, Rubin MA, Chang MC, Aster JC. French CA: diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody. Am J Surg Pathol. 2009;33:984–91.

    Article  PubMed  Google Scholar 

  25. Frierson HF Jr, Ross GW, Mills SE, Frankfurter A. Olfactory neuroblastoma. Additional immunohistochemical characterization. Am J Clin Pathol. 1990;94:547–53.

    PubMed  Google Scholar 

  26. Weinreb I, Goldstein D. Perez-Ordonez B: primary extraskeletal Ewing family tumor with complex epithelial differentiation: a unique case arising in the lateral neck presenting with Horner syndrome. Am J Surg Pathol. 2008;32:1742–8.

    Article  PubMed  Google Scholar 

  27. Seethala RR, Barnes EL, Hunt JL. Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol. 2007;31:44–57.

    Article  PubMed  Google Scholar 

  28. Seethala RR, Hunt JL, Baloch ZW, Livolsi VA, Leon Barnes E. Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature. Am J Surg Pathol. 2007;31:1683–94.

    Article  PubMed  Google Scholar 

  29. Bourne TD, Bellizzi AM, Stelow EB, Loy AH, Levine PA, Wick MR. Mills SE: p63 expression in olfactory neuroblastoma and other small cell tumors of the sinonasal tract. Am J Clin Pathol. 2008;130:213–8.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Dept of Pathology, UVA Health System, University of Virginia, Jefferson Park Ave., Box 800214, Charlottesville, VA, 22908, USA

    Edward B. Stelow

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  1. Edward B. Stelow
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Correspondence to Edward B. Stelow.

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Stelow, E.B. A Review of NUT Midline Carcinoma. Head and Neck Pathol 5, 31–35 (2011). https://doi.org/10.1007/s12105-010-0235-x

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  • DOI: https://doi.org/10.1007/s12105-010-0235-x

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