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Not Your Usual Cancer Case: Variants of Laryngeal Squamous Cell Carcinoma

  • Proceedings of the NASHNP Companion Meeting, February, 2011, San Antonio, TX
  • Published:
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Abstract

Although squamous cell carcinoma (SCC) variants account for less than 10% of all laryngeal SCCs, they have many unique biological, morphological, and clinical features. They are also easily confused with other tumor types. Recognition of them is critical for surgical pathologists as is the knowledge of what they mean for the patient. Three of the most common and important of these are basaloid, verrucous, and papillary SCC. These tumor types will be briefly reviewed with a focus on specific controversies, biological questions, and/or recent advancements in our understanding of them.

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References

  1. Ferlito A, Shaha AR, Silver CE, Rinaldo A, Mondin V. Incidence and sites of distant metastases from head and neck cancer. ORL J Otorhinolaryngol Relat Spec. 2001;63(4):202–7.

    CAS  PubMed  Google Scholar 

  2. Skarsgard DP, Groome PA, Mackillop WJ, et al. Cancers of the upper aerodigestive tract in Ontario, Canada, and the United States. Cancer. 2000;88(7):1728–38.

    Article  CAS  PubMed  Google Scholar 

  3. Begum S, Westra WH. Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status. Am J Surg Pathol. 2008;32(7):1044–50.

    Article  PubMed  Google Scholar 

  4. Chernock RD, Lewis JS Jr, Zhang Q, El-Mofty SK. Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma. Hum Pathol. 2010;41(7):1016–23.

    Article  CAS  PubMed  Google Scholar 

  5. Wain SL, Kier R, Vollmer RT, Bossen EH. Basaloid-squamous carcinoma of the tongue, hypopharynx, and larynx: report of 10 cases. Hum Pathol. 1986;17(11):1158–66.

    Article  CAS  PubMed  Google Scholar 

  6. Chernock RD, El-Mofty SK, Thorstad WL, Parvin CA, Lewis JS Jr. HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx: utility of microscopic features in predicting patient outcome. Head Neck Pathol. 2009;3(3):186–94.

    Article  PubMed  Google Scholar 

  7. Serrano MF, El-Mofty SK, Gnepp DR, Lewis JS Jr. Utility of high molecular weight cytokeratins, but not p63, in the differential diagnosis of neuroendocrine and basaloid carcinomas of the head and neck. Hum Pathol. 2008;39(4):591–8.

    Article  CAS  PubMed  Google Scholar 

  8. Morice WG, Ferreiro JA. Distinction of basaloid squamous cell carcinoma from adenoid cystic and small cell undifferentiated carcinoma by immunohistochemistry. Hum Pathol. 1998;29(6):609–12.

    Article  CAS  PubMed  Google Scholar 

  9. Soriano E, Faure C, Lantuejoul S, et al. Course and prognosis of basaloid squamous cell carcinoma of the head and neck: a case-control study of 62 patients. Eur J Cancer. 2008;44(2):244–50.

    Article  PubMed  Google Scholar 

  10. Calhoun KH, Fulmer P, Weiss R, Hokanson JA. Distant metastases from head and neck squamous cell carcinomas. Laryngoscope. 1994;104(10):1199–205.

    Article  CAS  PubMed  Google Scholar 

  11. Thariat J, Ahamad A, El-Naggar AK, et al. Outcomes after radiotherapy for basaloid squamous cell carcinoma of the head and neck: a case-control study. Cancer. 2008;112(12):2698–709.

    Article  PubMed  Google Scholar 

  12. Steffen C. The man behind the eponym: Lauren V. Ackerman and verrucous carcinoma of Ackerman. Am J Dermatopathol. 2004;26(4):334–41.

    Article  PubMed  Google Scholar 

  13. Koch BB, Trask DK, Hoffman HT, et al. National survey of head and neck verrucous carcinoma: patterns of presentation, care, and outcome. Cancer. 2001;92(1):110–20.

    Article  CAS  PubMed  Google Scholar 

  14. Ferlito A, Recher G. Ackerman’s tumor (verrucous carcinoma) of the larynx: a clinicopathologic study of 77 cases. Cancer. 1980;46(7):1617–30.

    Article  CAS  PubMed  Google Scholar 

  15. Orvidas LJ, Olsen KD, Lewis JE, Suman VJ. Verrucous carcinoma of the larynx: a review of 53 patients. Head Neck. 1998;20(3):197–203.

    Article  CAS  PubMed  Google Scholar 

  16. Syrjanen S. Human papillomavirus (HPV) in head and neck cancer. J Clin Virol. 2005;32(Suppl 1):S59–66.

    Article  PubMed  Google Scholar 

  17. Saito T, Nakajima T, Mogi K. Immunohistochemical analysis of cell cycle-associated proteins p16, pRb, p53, p27 and Ki-67 in oral cancer and precancer with special reference to verrucous carcinomas. J Oral Pathol Med. 1999;28(5):226–32.

    Article  CAS  PubMed  Google Scholar 

  18. Thompson LD, Wenig BM, Heffner DK, Gnepp DR. Exophytic and papillary squamous cell carcinomas of the larynx: a clinicopathologic series of 104 cases. Otolaryngol Head Neck Surg. 1999;120(5):718–24.

    Article  CAS  PubMed  Google Scholar 

  19. Cobo F, Talavera P, Concha A. Review article: relationship of human papillomavirus with papillary squamous cell carcinoma of the upper aerodigestive tract: a review. Int J Surg Pathol. 2008;16(2):127–36.

    Article  PubMed  Google Scholar 

  20. Jo VY, Mills SE, Stoler MH, Stelow EB. Papillary squamous cell carcinoma of the head and neck: frequent association with human papillomavirus infection and invasive carcinoma. Am J Surg Pathol. 2009;33(11):1720–4.

    Article  PubMed  Google Scholar 

  21. Suarez PA, Adler-Storthz K, Luna MA, El-Naggar AK, Abdul-Karim FW, Batsakis JG. Papillary squamous cell carcinomas of the upper aerodigestive tract: a clinicopathologic and molecular study. Head Neck. 2000;22(4):360–8.

    Article  CAS  PubMed  Google Scholar 

  22. Ishiyama A, Eversole LR, Ross DA, et al. Papillary squamous neoplasms of the head and neck. Laryngoscope. 1994;104(12):1446–52.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to James S. Lewis Jr..

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Lewis, J.S. Not Your Usual Cancer Case: Variants of Laryngeal Squamous Cell Carcinoma. Head and Neck Pathol 5, 23–30 (2011). https://doi.org/10.1007/s12105-010-0232-0

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