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Trabecular and Psammomatoid Juvenile Ossifying Fibroma of the Skull Base Mimicking Psammomatoid Meningioma

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Abstract

Ossifying fibroma (OF) is a fibro-osseous tumor that usually occurs in young people and arises in the craniofacial bones. We report a case of a 15-year-old boy who developed progressive proptosis and hypertelorism and was found to have a mid-face and skull base tumor, initially diagnosed as psammomatoid meningioma. The tumor recurred and the resected specimen revealed a unique OF having trabecular and psammomatoid features. The clinical, radiographic, histopathologic findings and differential diagnoses of the case are presented.

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References

  1. Slootweg PJ, El-Mofty S. Ossifying fibroma. In: Barnes L, Eveson JW, Reichart P, Sidransky D, editors. Pathology and genetics of head and neck tumours. Lyon: IARC; 2005. p. 319–20.

    Google Scholar 

  2. Taxy JB. Meningioma of the paranasal sinuses. A report of two cases. Am J Surg Pathol. 1990;14:82–6.

    Article  CAS  PubMed  Google Scholar 

  3. Thompson LD, Gyure KA. Extracranial sinonasal tract meningiomas: a clinicopathologic study of 30 cases with a review of the literature. Am J Surg Pathol. 2000;24:640–50.

    Article  CAS  PubMed  Google Scholar 

  4. Swain RE Jr, Kingdom TT, DelGaudio JM, et al. Meningiomas of the paranasal sinuses. Am J Rhinol. 2001;15:27–30.

    Article  PubMed  Google Scholar 

  5. Cruz AA, Alencar VM, Figueiredo AR, et al. Ossifying fibroma: a rare cause of orbital inflammation. Ophthal Plast Reconstr Surg. 2008;24:107–12.

    Article  PubMed  Google Scholar 

  6. Margo CE, Ragsdale BD, Perman KI, et al. Psammomatoid (juvenile) ossifying fibroma of the orbit. Ophthalmology. 1985;92:150–9.

    CAS  PubMed  Google Scholar 

  7. Johnson LC, Yousefi M, Vinh TN, et al. Juvenile active ossifying fibroma. Its nature, dynamics and origin. Acta Otolaryngol Suppl. 1991;488:1–40.

    CAS  PubMed  Google Scholar 

  8. Slootweg PJ, Panders AK, Nikkels PG. Psammomatoid ossifying fibroma of the paranasal sinuses. An extragnathic variant of cemento-ossifying fibroma. Report of three cases. J Craniomaxillofac Surg. 1993;21:294–7.

    CAS  PubMed  Google Scholar 

  9. Wenig BM, Vinh TN, Smirniotopoulos JG, et al. Aggressive psammomatoid ossifying fibromas of the sinonasal region: a clinicopathologic study of a distinct group of fibro-osseous lesions. Cancer. 1995;76:1155–65.

    Article  CAS  PubMed  Google Scholar 

  10. Dhingra KK, Khurana N, Chatturvedi KU. Aggressive psammomatoid ossifying fibroma (APOF): two cases with short review. Pathology. 2008;40:418–20.

    Article  PubMed  Google Scholar 

  11. Granados R, Carrillo R, Najera L, et al. Psammomatoid ossifying fibromas: immunohistochemical analysis and differential diagnosis with psammomatous meningiomas of craniofacial bones. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:614–9.

    Article  PubMed  Google Scholar 

  12. Noudel R, Chauvet E, Cahn V, et al. Transcranial resection of a large sinonasal juvenile psammomatoid ossifying fibroma. Childs Nerv Syst. 2009;25:1115–20.

    Article  PubMed  Google Scholar 

  13. El-Mofty S. Psammomatoid and trabecular juvenile ossifying fibroma of the craniofacial skeleton: two distinct clinicopathologic entities. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;93:296–304.

    Article  PubMed  Google Scholar 

  14. Makek M. Clinical pathology and differential diagnosis of fibro-osseous lesions of the maxillofacial area–new aspects. Dtsch Z Mund Kiefer Gesichtschir. 1986;10:212–7.

    CAS  PubMed  Google Scholar 

  15. Han MH, Chang KH, Lee CH, et al. Sinonasal psammomatoid ossifying fibromas: CT and MR manifestations. AJNR Am J Neuroradiol. 1991;12:25–30.

    CAS  PubMed  Google Scholar 

  16. Feldman LA, Tabor MH, Mirani N. Pathologic quiz case: a sino-orbital mass in a 13-year-old adolescent girl. Arch Pathol Lab Med. 2003;127:e301–2.

    PubMed  Google Scholar 

  17. Slootweg PJ, Panders AK, Koopmans R, et al. Juvenile ossifying fibroma. An analysis of 33 cases with emphasis on histopathological aspects. J Oral Pathol Med. 1994;23:385–8.

    Article  CAS  PubMed  Google Scholar 

  18. Toyosawa S, Yuki M, Kishino M, et al. Ossifying fibroma vs. fibrous dysplasia of the jaw: molecular and immunological characterization. Mod Pathol. 2007;20:389–96.

    Article  CAS  PubMed  Google Scholar 

  19. Jundt G. Fibrous dysplasia. In: Barnes L, Eveson JW, Reichart P, Sidransky D, editors. Pathology and genetics of head and neck tumours. Lyon: IARC; 2005. p. 321–2.

    Google Scholar 

  20. Voytek TM, Ro JY, Edeiken J, et al. Fibrous dysplasia and cemento-ossifying fibroma. A histologic spectrum. Am J Surg Pathol. 1995;19:775–81.

    Article  CAS  PubMed  Google Scholar 

  21. Williams HK, Mangham C, Speight PM. Juvenile ossifying fibroma. An analysis of eight cases and a comparison with other fibro-osseous lesions. J Oral Pathol Med. 2000;29:13–8.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Marino E. Leon.

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Bohn, O.L., Kalmar, J.R., Allen, C.M. et al. Trabecular and Psammomatoid Juvenile Ossifying Fibroma of the Skull Base Mimicking Psammomatoid Meningioma. Head and Neck Pathol 5, 71–75 (2011). https://doi.org/10.1007/s12105-010-0212-4

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  • DOI: https://doi.org/10.1007/s12105-010-0212-4

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