Angiosarcoma of the Oral Cavity

Abstract

Angiosarcoma of the oral cavity is extremely rare. A 54-year-old woman consulted to our hospital because of mass of the left cheek next to the mandible. MRI showed a 1 cm tumor. Enucleation of the tumor was performed. Grossly, the tumor was not encapsulated and had a central cavity. Histologically, the tumor consisted of spindle and polygonal cells with hyperchromatic nuclei with nucleoli. Intracytoplasmic vacuoles and mitotic figure were scattered. Vasoformative channels were present in some areas. Lymphoid follicles were scattered in the tumor. The tumor was invasive into the surrounding tissue, and lymphovascular permeation was noted. The surgical margins were positive. Immunohistochemically, the tumor cells were positive for factor VIII-related antigen, CD31, CD34, vimentin, p53 protein, but negative for pancytokeratins, cytokeratin (CK) 7, CK 18, CK19, EMA, S100 protein, α-smooth muscle antigen, desmin, p63, synaptophysin, chromogranin, neuron-specific enolase, CD56, CD10, CD20, CD30, CD45RO, melanosome, myoglobin, KIT, and PDGFRA. The Ki-67 labeling was 46%. The lymphoid tissue in the tumor was positive for CD20, CD45, CD45RO, and CD10. A pathological diagnosis of angiosarcoma was made. No metastatic lesions are found now. Radical operation is planned now.