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Fascin Over Expression is Associated with Dysplastic Changes in Sinonasal Inverted Papillomas: A Study of 47 Cases

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Abstract

Sinonasal inverted papilloma (IP) is a primary benign lesion with a tendency for local recurrence. Malignant transformation may develop in up to 15% of cases. Fascin (Fascin 1) is an actin cross-link binding protein required for the formation of actin-based cell-surface protrusions and cell motility. Fascin up-regulation in lung, gastric, breast and hepatobiliary carcinomas correlates with aggressiveness and decreased survival. Here we evaluate immunohistochemical expression of fascin in 47 sinonasal IPs from 34 patients. Fascin over-expression is significantly more common in sinonasal IP with high-grade dysplasia than in those with no dysplastic or low-grade dysplastic epithelium (P = 0.0001). No significant change in fascin expression is seen with recurrence. Over expression of fascin in high-grade dysplastic epithelium in IP may be associated with tumor progression and malignant transformation.

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Acknowledgments

Part of this study was presented at the 97th USCAP annual meeting in Denver in 2008.

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Authors and Affiliations

  1. Department of Pathology, New York University School of Medicine, New York, NY, USA

    Hope H. Wu, Samiah Zafar, Herman Yee, Luis Chiriboga & Beverly Y. Wang

  2. Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA

    Youming Huan

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  1. Hope H. Wu
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  2. Samiah Zafar
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  3. Youming Huan
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  4. Herman Yee
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  5. Luis Chiriboga
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  6. Beverly Y. Wang
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Correspondence to Beverly Y. Wang.

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Wu, H.H., Zafar, S., Huan, Y. et al. Fascin Over Expression is Associated with Dysplastic Changes in Sinonasal Inverted Papillomas: A Study of 47 Cases. Head and Neck Pathol 3, 212–216 (2009). https://doi.org/10.1007/s12105-009-0133-2

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  • DOI: https://doi.org/10.1007/s12105-009-0133-2

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