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Solitary Fibrous Tumor of the Oral Cavity: Clinicopathologic and Immunohistochemical Study of 21 Cases

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Abstract

We describe clinical, morphologic, and immunohistochemical features of 21 cases of solitary fibrous tumor presenting in the oral cavity. There were 9 male and 12 female patients with a median age of 51 years (range 37–83). The most common locations included the buccal mucosa (the most common site), lip, maxillary or mandibular vestibule and tongue. Histopathologic examination showed well-circumscribed tumors with two well-defined patterns: the classic pattern with densely cellular areas alternating with hypocellular areas in a variably collagenous, vascular stroma and a more uniformly sclerotic pattern with only subtle classic areas. The spindle-shaped neoplastic cells consistently showed immunoreactivity for antibodies directed against CD34. Five of nineteen cases (26%) were reactive for CD99 and 19 of 19 for Bcl-2. Follow-up information was available in 17 cases and averaged 54 months, with no evidence of recurrence or metastasis in any of these patients. Awareness that solitary fibrous tumor may present in the oral cavity is important so that confusion with other spindle cell neoplasms can be avoided. We also briefly describe the differential diagnosis and compare this series, the largest single series of intraoral SFT, to cases previously reported in the literature.

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Acknowledgements

We would like to thank Christopher Fletcher MD who helped review the cases, and all contributing doctors who provided the material for this study.

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Authors and Affiliations

  1. Oral Maxillofacial Pathology, Dublin Dental School and Hospital, Dublin, Ireland

    Esther M. O’Regan

  2. Immunology Research Division, Harvard Medical School/Brigham and Womens Hospital, Boston, MA, USA

    Vijay Vanguri

  3. College of Dentistry, The Ohio State University, Columbus, OH, USA

    Carl M. Allen

  4. Oral Pathology Diagnostic Services, San Diego, CA, 92111, USA

    Lewis Roy Eversole

  5. Department of Diagnostic Sciences, Texas A & M Health Center, Baylor College of Dentistry, Dallas, TX, USA

    John M. Wright

  6. Harvard School of Dental Medicine, Pathology Services Inc, Cambridge, Brigham and Womens Hospital, Boston, MA, USA

    Sook-Bin Woo

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  1. Esther M. O’Regan
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Correspondence to Esther M. O’Regan.

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O’Regan, E.M., Vanguri, V., Allen, C.M. et al. Solitary Fibrous Tumor of the Oral Cavity: Clinicopathologic and Immunohistochemical Study of 21 Cases. Head and Neck Pathol 3, 106–115 (2009). https://doi.org/10.1007/s12105-009-0111-8

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