Abstract
Objectives
To study the neurodevelopmental status of offsprings of mothers with gestational diabetes (OGDM) aged 3½ mo.
Methods
This cross-sectional study was conducted at a tertiary hospital, New Delhi which included infants aged 3½ mo (+1 wk) who were either offsprings of women with gestational diabetes (cases) or infants of mothers without gestational diabetes mellitus presenting to tertiary care public hospital in India from January, 2018 through March, 2019, with enrollment of infants done between 10 April, 2018 and 30 March, 2019.
Results
The development quotient (DQ) using Developmental Assessment Scales for Indian Infants (DASII) was calculated as Motor DQ, Mental DQ and a composite DQ. The mean motor DQ of the enrolled infants was 101.7 (12.02); it was significantly lower for OGDM than controls [101 (1.41) vs. 109.5 (10.6); P <0.001]. The mean mental DQ of the enrolled infants was 88.9 (12.0); it was significantly lower for OGDM than the control group [84 (9.89 vs. 88 (8.48); P = 0.03]. The total development quotient for the enrolled infants was 95.3 (11.3). The total development quotient for study group was significantly lower than the control group [92.5 (5.65) vs. 98.75 (9.54); P = 0.001].
Conclusions
The mean motor, mental total DQ of offsprings of mothers with GDM were significantly lower than those born to mothers without GDM. Hence follow up, early intervention should be considered for this high risk group.
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DM: Conceived the study idea, planned the protocol, conducted the data analysis and finalized the manuscript; RB: Enrolled and evaluated the subjects, collected the data, assisted in study planning and data analysis, and prepared the initial draft of the manuscript; MJ, DK and SG: Provided inputs in study planning, and patient enrolment and evaluation. They also provided important intellectual inputs in study design and manuscript preparation. All authors approved the final manuscript, and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. DM shall be the guarantor for this manuscript.
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Received first prize at 6th National Symposium on Growth, Pediatric and Adolescent Endocrinology, 2022.
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Bersain, R., Mishra, D., Juneja, M. et al. Comparison of Neurodevelopmental Status in Early Infancy of Infants of Women With and Without Gestational Diabetes Mellitus. Indian J Pediatr 90, 1083–1088 (2023). https://doi.org/10.1007/s12098-023-04639-0
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DOI: https://doi.org/10.1007/s12098-023-04639-0