Abstract
In this case report the authors present an extremely low birth weight premature infant with neonatal brucellosis whose mother had been treated for brucellosis during pregnancy. Infant developed mild respiratory distress syndrome soon after birth. At 2nd wk of postnatal age findings of bronchopulmonary dysplasia were evident and she and her mother were diagnosed to have brucellosis at the same time. After commencement of antibrucellosis therapy and nonspesific treatment for bronchopulmonary dysplasia, infant was completely cured of the symptoms related to both brucellosis and bronchopulmonary dysplasia. The results of the present case and a review of the literature have let to conclude that Brucella might have role in development of prematurity and bronchoplumonary dysplasia. Since discovery of brucella bacilli in early periods of 20th century, fetotoxicity of brucella bacilli seems to increase gradually suggesting an increasing virulance of the bacilli or vanishing host defense of human beings.
References
Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new global map of human brucellosis. Lancet Infect Dis. 2006;6:91–9.
Kurdoglu M, Adali E, Kurdoglu Z, Karahocagil MK, Kolusari A, Yildizhan R, et al. Brucellosis in pregnancy: a 6-year clinical analysis. Arch Gynecol Obstet. 2010;281:201–6.
Koklu E, Buyukkayhan D, Akcakus M, Kurtoglu S, Koklu S, Gunes T. Brucellosis with pulmonary involvement in a premature infant. Ann Trop Paediatr. 2006;26:367–70.
Chheda S, Lopez SM, Sanderson EP. Congenital brucellosis in a premature infant. Pediatr Infect Dis J. 1997;16:81–3.
Carpenter CM, Boak R. Brucella Abortus in Milk and Dairy Products. Am J Public Health Nations Health. 1928;18:743–51.
Poele PM, Whitehouse DB, Gilchrist MM. A case of abortion consequent upon infection with Brucella abortus biotype 2. J Clin Pathol. 1972;25:882–4.
Young EJ. Human brucellosis. Rev Infect Dis. 1983;5:821–42.
Elshamy M, Ahmed AI. The effects of maternal brucellosis on pregnancy outcome. J Infect Dev Ctries. 2008;2:230–4.
Williamson AR. Abortion in Brucella abortus Fever. Br Med J. 1944;1:752.
Gloeb DJ, Lupi C, O’Sullivan MJ. Neurobrucellosis complicating pregnancy: a case report. Infect Dis Obstet Gynecol. 1994;1:285–9.
Khan MY, Mah MW, Memish ZA. Brucellosis in pregnant women. Clin Infect Dis. 2001;32:1172–7.
Sayılır K, Sayın Kutlu S, Baykam N, et al. Spontaneous abortion due to brucellosis: Report of two cases. Turk J Infect. 2003;17:345–8.
Mosayebi Z, Movahedian AH, Ghayomi A, Kazemi B. Congenital brucellosis in a preterm neonate. Indian Pediatr. 2005;42:599–601.
Arroyo Carrera I, López Rodríguez MJ, Sapiña AM, López Lafuente A, Sacristán AR. Probable transmission of brucellosis by breast milk. J Trop Pediatr. 2006;52:380–1.
Imani R, Shamsipoor E, Khadivi R. Congenital brucellosis in an infant. Iran J Clin Infect Dis. 2007;2:29–31.
Çetin N, Akduman İ, Kaya A, Helvacı M, İnce Bağ Ö. A case of neonatal brucellosis. Tepecik Eğit Hast Derg. 2009;19:46–8.
Karcaaltincaba D, Sencan I, Kandemir O, Guvendag-Guven ES, Yalvac S. Does brucellosis in human pregnancy increase abortion risk? Presentation of two cases and review of literature. J Obstet Gynaecol Res. 2010;36:418–23.
Conflict of Interest
None
Role of Funding Source
None
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ceylan, A., Köstü, M., Tuncer, O. et al. Neonatal Brucellosis and Breast Milk. Indian J Pediatr 79, 389–391 (2012). https://doi.org/10.1007/s12098-011-0581-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12098-011-0581-z