Abstract
The authors report 22 patients of Kawasaki disease, diagnosed and treated over a period of 3 years at a tertiary care centre in New Delhi. Ten cases fullfiled the criteria of a “classical” case while 12 cases were “incomplete” cases. Echocardiography was performed in all cases and coronary artery involvement was found in 8 (36%) cases. All cases received high dose Intravenous Immunoglobulins (IVIG) as standard therapy. In two cases, a repeat dose of IVIG was required for defervescence to occur. All cases recovered after therapy. Those with coronary artery involvement were planned for a 2 years follow up from the time of diagnosis.
References
Kawasaki T, Kosaki F. Febrile oculo-oro-cutaneo-acro-desquamatous ndrome with or without acute non-suppurative cervical lymphadenitis in infancy and childhood: clinical observations of 50 cases. Arerugi. 1967;16:178–222.
Kawasaki T, Kosaki F, Okawa S, et al. A new infantile acute febrile mucocutaneous lymph syndrome (MLNS) prevailing in Japan. Pediatrics. 1974;54:271–6.
Taneja A, Saxena U. Mucocutaneous lymph node syndrome. Indian Pediatr. 1977;14:927–31.
Cimaz R, Sundel R. Atypical and incomplete Kawasaki disease, best practice & research clinical rheumatology. Pediatr Rheumatol. 2009;23:689–97.
Rowley AH, Duffy CE, Shulman ST. Prevention of giant aneurysms in Kawasaki Disease by intravenous gammaglobulin therapy. J Pediatr. 1988;113:290–4.
Khubchandani R. Kawasaki disease–call for a national registry for India. Indian Pediatr. 2010;47:200.
Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation. 2004;110:2747–71.
de Zorzi A, Colan SD, Gauvreau K, Baker AL, Sundel RP, Newburger JW. Coronary artery dimensions may be misclassified as normal in Kawasaki Disease. J Pediatr. 1998;133:254–8.
Kurotobi S, Nagai T, Kawakami N, Sano T. Coronary diameter in normal infants, children and patients with Kawasaki Disease. Pediatr Int. 2002;44:1–4.
Durongpisitkul K, Gururaj VJ, Park JM, Martin CF. The prevention of coronary artery aneurysm in Kawasaki Disease: a meta-analysis on the efficacy of aspirin and immunoglobulin treatment. Pediatrics. 1995;96:1057–61.
Acknowledgements
Dr. Chandrashekhar Singha and Dr. SK Nakra helped a great deal in evolution of this paper. Dr. Rohit Arora was responsible for proof reading and final shaping of the article. All Pediatricians associated with Max Superspecialty contributed in the collection of clinical material.
Contributions
MC was responsible for collection and collation of data while SM performed echocardiography of all patients. AT conceived and designed the study as well as reviewed relevant literature.
Conflict of Interest
None.
Role of Funding Source
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Consul, M., Mishra, S. & Taneja, A. Spectrum of Kawasaki Disease. Indian J Pediatr 78, 488–490 (2011). https://doi.org/10.1007/s12098-010-0356-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12098-010-0356-y