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Anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis

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Abstract

Objective

Prevalence and clinical significance of anti-cyclic citrullinated peptide (CCP) antibodies in Indian patients with juvenile idiopathic arthritis (JIA).

Methods

Anti-CCP antibodies were determined by enzyme-linked immunosorbent assay (ELISA) in 78 patients with JIA which included all 3 major subtypes of the disease: pauciarticular, polyarticular afld systemic onset. Values above 5 relative units were taken as positive. Associations between antiCCP antibodies and clinical and laboratory and radiological parameters were determined.

Results

Anti-CCP antibodies were positive in only 2 of 34 (5.9%) patients with pauciarticular JIA and 3 of 17 (17.6%) of systemic,.pnset JIA, whereas it was positive in 13 of 27 (48.1%) of polyarticular JIA patients (p < 0.001). Furthermore, it was seen that among patients with polyarticular JIA, RF-lgM positive patients had higher rate of anti-CCP antibody positivity with 7 of 8 (87.5%) patients having positive anti-CCP antibody (p<0.001). Similarly, patients with erosions (11/19; p<0.001) and deformities (5/−10; p<0.001) were found to have significant association with anti-CCP antibody positivity.

Conclusion

Anti-CCP antibodies could be detected more frequently in the sera of JIA patients with severe manifestations like-erosions and deformity. It was also more significantly associated with seropositive polyarticular JIA than other types. It can be presumed from these results that anti-CCP antibodies can be used as a marker to predict severe course of JIA at the onset to guide optimal aggressive therapy.

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Authors and Affiliations

  1. Clinical Immunology and Rheumatology Services, New Delhi, India

    R. Gupta, M. M. Thabah & B. Vaidya

  2. Department of Medicine, Maulana Azad Institute of Dental Sciences, New Delhi, India

    S. Gupta

  3. Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India

    R. Lodha & S. K. Kabra

  4. Department of Medicine, All India Institute of Medical Sciences, New Delhi, 110029, India

    R. Gupta

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  1. R. Gupta
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  2. M. M. Thabah
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  3. B. Vaidya
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  4. S. Gupta
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Correspondence to R. Gupta.

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Gupta, R., Thabah, M.M., Vaidya, B. et al. Anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis. Indian J Pediatr 77, 41–44 (2010). https://doi.org/10.1007/s12098-010-0006-4

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  • DOI: https://doi.org/10.1007/s12098-010-0006-4

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