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Validation of initial serum creatinine as a predictive factor for development of end stage renal disease in posterior urethral valves

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Abstract

Objective

The aim of this study was to determine the value of initial serum creatinine in prediction of End-stage renal disease (ESRD) in children with posterior urethral valves PUV.

Methods

In this retrospective study, patients diagnosed with PUV admitted in Aliasghar Children’s Hospital in Tehran, Iran from 1991 through 2001 were studied. Based on the development of ESRD (need for dialysis) they were classified in two groups and their demographics, initial presentations, laboratory data, imaging findings and outcomes were reviewed and compared.

Results

Thirty six male patients with PUV, treated with valve ablation (13), vesicostomy (13), or high ureterostomy (10) were followed for developing ESRD. Sixteen of the 36 patients developed ESRD at their last follow-up. There was no significant difference in age at initial presentation, presence of urinary tract infections, incidence of vesicoureteral reflux, renal dysplasia or type of primary surgical intervention between the patients with or without ESRD. Patients who progressed to ESRD had serum creatinine concentration > 1.0 mg/dl at diagnosis as compared to those without ESRD (P = 0.001).

Conclusion

Initial serum creatinine is a valuable factor for prediction of renal outcome in patients with PUV.

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References

  1. Lopez Pereira P, Martinez Urrutia Mj, Jaurequizar E. Initial and long term management of posterior urethral valves. World J Urol 2004; 22: 418–424.

    Article  PubMed  CAS  Google Scholar 

  2. Tejani A, Butt K, Glassberg K et al. Predictors of eventual end stage renal disease in children with posterior urethral valves. J Urol 1986; 136: 857–860.

    PubMed  CAS  Google Scholar 

  3. Bajpai M, Dave S, Gupta DK. Factor affecting outcome in the management of posterior urethral valves. Pediatr Surg 2001; 17: 11–15.

    Article  CAS  Google Scholar 

  4. Drozdz D, Drozdz M, Gretz N et al. Progression to end-stage renal disease in children with posterior urethral valves. Pediatr Nephrol 1998; 12: 630–636.

    Article  PubMed  CAS  Google Scholar 

  5. Onuora VC, Mirza K, Koko AH et al. Prognostic factors in Saudi children with posterior urethral. Pediatr Nephrol 2000; 14: 221–223.

    Article  PubMed  CAS  Google Scholar 

  6. Denes ED, Barthold JS, Gonzalez R. Early prognostic value of serum creatinine levels in children with posterior urethral valves. J Urol 1997; 157: 1441–1443.

    Article  PubMed  CAS  Google Scholar 

  7. Ghanem MA, Wolffenbuttel KP, De Vylder. A Long term bladder dysfunction and renal function in boys with posterior urethral valves based on urodynamic findings. J Urol 2004; 171: 2409–2412.

    Article  PubMed  Google Scholar 

  8. Merguerian PA, McLorie GA, Churchill BM et al. Radiographic and serologic correlates of azotemia in patients with posterior urethral valves. J Urol 1992; 148: 1499–1503.

    PubMed  CAS  Google Scholar 

  9. Lai R, Bhatnagar V, Mitra DK. Long term prognosis of renal function in boys treated for posterior urethral valves. Eur J Pediatr 1999; 9: 307–311.

    Google Scholar 

  10. Lopez Pereira P, Espinosa L, Martinez Urrutina R. Posterior urethral valves: prognostic factors. Br J Urol 2003; 91: 687–690.

    CAS  Google Scholar 

  11. Sherbiny Mt, Hafez AT, Shokeia AA. Posterior urethral valves: does young age at diagnosis correlate with poor renal function? Urology 2002; 60: 335–338.

    Article  PubMed  Google Scholar 

  12. Hutton KAR, Thomas DFM, Arthur RJ et al. Prenatally detected posterior urethral valves: Is gestational age at detection a predictor of outcome? J Urol 2002; 152: 698–701.

    Google Scholar 

  13. Ylinen E, Ala-Houhala M, Wikstrom S. Prognostic factors of posterior urethral valves and the role of antenatal detection. Pediatr Nephrol 2004; 19: 874–879.

    PubMed  Google Scholar 

  14. Reinberg Y, deCastano I, Gonzalez R. Prognosis for patients with prenatally diagnosed posterior urethral valves. J Urol 1992; 148: 125–126.

    PubMed  CAS  Google Scholar 

  15. Assadi F, John EG, Justice P, Fornel L. Beta 2-microglobulin clearance in neonates: Index of tubular maturation. Kidney Int 1985; 28: 153–157.

    Article  PubMed  CAS  Google Scholar 

  16. Norman ME, Assadi F. A prospective study of acute renal failure in the newborn infant. Pediatrics 1979; 63: 475–479.

    PubMed  CAS  Google Scholar 

  17. Kukreja RA, Desai RM, Sabnis RB. Outcome of children with posterior urethral valves: Prognostic factors. Ind J Urol 2001; 17: 141–144.

    Google Scholar 

  18. Jee LD, Rickwood AM, Turnock RR. Posterior urethral valves: Does prenatal diagnosis influence prognosis? Br J Urol 1994; 74: 134–136.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatric Nephrology, Iran University of Medical Sciences, Tehran, Iran

    Azar Nickavar, Hassan Otoukesh & Kambiz Sotoudeh

Authors
  1. Azar Nickavar
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  2. Hassan Otoukesh
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  3. Kambiz Sotoudeh
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Correspondence to Azar Nickavar.

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Nickavar, A., Otoukesh, H. & Sotoudeh, K. Validation of initial serum creatinine as a predictive factor for development of end stage renal disease in posterior urethral valves. Indian J Pediatr 75, 695–697 (2008). https://doi.org/10.1007/s12098-008-0090-x

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  • DOI: https://doi.org/10.1007/s12098-008-0090-x

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