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Impact of pre-radiation therapy quality of life in lung cancer survival: a prospective, intention-to-treat, multicenter study

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Abstract

Purpose

Lung cancer (LC) has a significant impact on patients’ health-related quality of life (HRQoL). We investigate the correlations between pre-radiation therapy HRQoL and survival.

Materials and methods

A prospective, intention-to-treat, multicentre study of 437 patients with LC recruited at the radiation oncology departments of three different institutions was conducted between 2012 and 2016. QoL was assessed using the EORTC-QLQ-C30 (v3.0) and EORTC-QLQ-LC13 questionnaires. Global health status (GHS), physical (PF), role functioning (RF), emotional (EF), cognitive (CF), and social functioning (SF) as well as symptoms scores were evaluated in univariate and multivariate analyses.

Results

The cohort consisted of 376 men (86%) and 61 women, with a median age of 66 years (range 31–88). Histology was: 72% (n = 315) non-small cell lung cancer and 28% small cell lung cancer. The most common stage was III (80%) and the median follow-up for alive patients was 30 months (range 7–76). Multivariate analysis showed that RF was associated with a lower risk of mortality (HR: 0.693; p = 0.008) and recurrence (HR: 0.737; p = 0.040). Additionally, lower scores on EF and PF were associated with higher mortality (HR: 0.696; p = 0.003 and HR: 0.765; p = 0.044, respectively). Appetite loss, constipation, and dysphagia were associated with a higher risk of mortality (HR: 1.985; p < 0.001, HR: 1.373; p = 0.036, and HR: 1.659; p = 0.002, respectively), while appetite loss was the only symptom associated with a higher risk of recurrence (HR: 1.525; p = 0.014).

Conclusions

Pre-radiation therapy scores on RF, EF, and PF and symptoms like appetite loss, dysphagia, and constipation were associated with the risk of mortality. This information could be added to other prognostic factors to guide our treatment decisions.

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Acknowledgements

This work was supported by grants from ISCIII (Fis: PI13/01155, PI16/02104) and Consejeria de Salud of the Junta de Andalucia (PI-0096–2012).

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Authors and Affiliations

  1. Department of Radiation Oncology, Virgen del Rocío University Hospital, Manuel Siurot Avenue, s/n. 41013, Seville, Spain

    J. M. Nieto-Guerrero Gómez, G. P. Silva Vega, B. D. Delgado León, M. J. Ortiz Gordillo & J. L. López Guerra

  2. Department of Radiation Oncology, Cruces University Hospital, Bilbao, Spain

    J. Cacicedo

  3. Department of Medical Oncology, Virgen del Rocío University Hospital, Seville, Spain

    D. Herrero Rivera

  4. Methodology Unit, Virgen del Rocío University Hospital, Seville, Spain

    J. M. Praena Fernández

  5. Department of Radiation Oncology, Tenon University Hospital, Hôpitaux Universitaires Est Parisien, Sorbonne University Medical Faculty, Paris, France

    E. Rivin del Campo

  6. Instituto de Biomedicina de Sevilla (IBIS/HUVR/CSIC/Universidad de Sevilla), Seville, Spain

    M. J. Ortiz Gordillo & J. L. López Guerra

  7. Master of Cognitive and Behavioral Neuroscience, University of Granada, Granada, Spain

    G. P. Silva Vega

Authors
  1. J. M. Nieto-Guerrero Gómez
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  2. G. P. Silva Vega
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  3. J. Cacicedo
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  4. B. D. Delgado León
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  5. D. Herrero Rivera
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  6. J. M. Praena Fernández
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  7. E. Rivin del Campo
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  8. M. J. Ortiz Gordillo
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  9. J. L. López Guerra
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Corresponding author

Correspondence to J. L. López Guerra.

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All persons listed as authors have given their approval for the submission of the paper. Authors declare that we do not have any financial support or relationships that may suppose conflict of interest.

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Nieto-Guerrero Gómez, J.M., Silva Vega, G.P., Cacicedo, J. et al. Impact of pre-radiation therapy quality of life in lung cancer survival: a prospective, intention-to-treat, multicenter study. Clin Transl Oncol 22, 1635–1644 (2020). https://doi.org/10.1007/s12094-020-02310-0

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  • DOI: https://doi.org/10.1007/s12094-020-02310-0

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