Abstract
Objective
In this study, we aimed to discuss the clinical significance of CD4+CD25hiCD127low regulatory T cells (Tregs) in the peripheral blood of patients with non-small cell lung cancer (NSCLC).
Methods
Sixty patients with NSCLC and 35 healthy controls were studied. Peripheral blood CD4+CD25hiCD127lowTregs, CD4+CD25hiT cells, and CD4+T cells were measured with flow cytometric analysis, and results were compared between the groups.
Results
Compared with healthy people, CD4+CD25hiCD127low Tregs and CD4+CD25hi T cells significantly increased in patients with NSCLC, while CD4+ T cell proportions decreased.
Conclusions
CD4+CD25 hi CD127low Treg detection in the peripheral blood of NSCLC patients is highly significant, in that it provides additional knowledge to guide the selection of individualized treatment plans for patients with NSCLC.
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Funding
This project was supported by projects of the Suzhou industrial technology innovation (applied basic research of the people’s Livelihood technology and applied health care), Digestive Diseases and Nutrition Research Key Laboratory of Suzhou and Youth Project of Health and Family Planning Bureau of Suzhou High-tech Zone. The project numbers were SYSD2016062, SZS201620, and 2017Q005 respectively.
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All procedures performed in this study which involved human participants were conformed to the ethical standards of the institutional and/or national research committee and to the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
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Qiu, J., Che, G., Liu, F. et al. The detection and clinical significance of peripheral regulatory CD4+CD25hiCD127low T cells in patients with non-small cell lung cancer. Clin Transl Oncol 21, 1343–1347 (2019). https://doi.org/10.1007/s12094-019-02063-5
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DOI: https://doi.org/10.1007/s12094-019-02063-5