Abstract
Background
Our study analyzes the incidence of sleep problems and their mediating role on depression and anxious preoccupation in patients with resected, non-advanced cancer.
Methods
A multi-institutional, prospective, observational study was conducted with 750 participants of 14 hospitals in Spain. Participants’ socio-demographic and clinical characteristics were collected using a standardized self-report form and using EORTC QoL-QLQ-C30, BSI, Mini-MAC questionnaires.
Results
In women, sleep problems, depression and anxious preoccupation were observed in 65, 41 and 21%, respectively. In men, sleep problems, depression and anxious preoccupation were reported in 51, 29 and 61%, respectively. More sleep problems, depression and anxious preoccupation were found among women than males. Depression was a significant predictor of anxious preoccupation. In males, sleep problems partially mediated this association. This was not confirmed in women.
Conclusion
Our findings point toward the importance of developing interventions that decrease depression and sleep problems in cancer.
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Acknowledgements
The authors would like to thank the investigators of the NEOcoping study, the Supportive Care Working Group of the Spanish Society of Medical Oncology (SEOM), Natalia Cateriano, Miguel Vaquero and IRICOM S.A. for the support of the website registry, and Priscilla Chase Duran for editing the manuscript.
Funding
This work was funded by the Spanish Society of Medical Oncology (SEOM) in 2015. The sponsor of this research has not participated in data collection, analysis, or interpretation, in writing the report, or in the decision to submit the article for publication.
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The study has been performed in accordance with the ethical standards of the Declaration of Helsinki and its later amendments. This study is an observational, non-interventionist trial.
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Calderon, C., Carmona-Bayonas, A., Hernandez, R. et al. Incidence of sleep problems and their mediating role on depression and anxious preoccupation in patients with resected, non-advanced cancer: data from NEOcoping study. Clin Transl Oncol 21, 1104–1107 (2019). https://doi.org/10.1007/s12094-018-02018-2
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DOI: https://doi.org/10.1007/s12094-018-02018-2