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Up-regulation of microRNA-183-3p is a potent prognostic marker for lung adenocarcinoma of female non-smokers

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Abstract

Background

Lung cancer in never smokers presents predominately as adenocarcinoma and in females. MicroRNA-183 (miR-183) has various expression patterns in types of human cancers. In the present study, we evaluated the expression of miR-183-3p in female lung adenocarcinoma and adjacent noncancerous tissues and explored its relationship with clinicopathological characteristics and prognosis.

Methods

In the present study, a hundred female nonsmoking patients who were newly diagnosed and histologically confirmed as lung adenocarcinoma at Tianjin Medical University Cancer Hospital were included. miR-183-3p expression of surgically removed NSCLC tissues and their corresponding normal lung tissues was measured by qRT-PCR assay. Associations of miR-183-3p expression with clinicopathological features were determined using the Student’s t test. Log-rank test, and Cox proportional hazards model were used for survival analysis.

Results

At first, miR-183-3p was up-regulated in lung cancer tissues when compared with the corresponding noncancerous lung tissues. Moreover, the expression of miR-183-3p in tumor tissue was found to be associated with lymph node metastasis (P = 0.043), clinical stage (P = 0.015), and EGFR mutation (P = 0.003). At last, high miR-183-3p expression was also associated with both poor overall survival and progression-free survival of women with lung adenocarcinoma (P = 0.005 and P = 0.010, respectively).

Conclusion

This study suggested that miR-183-3p expression might be involved in lung cancer pathogenesis and progression, and could be used as a potential prognostic biomarker of female lung adenocarcinoma.

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Acknowledgments

Research support: this study was supported by National Natural Science Foundation of China (No. 81372229) and Natural Science Foundation of Tianjin (No. 13JCYBJC23100).

Conflict of interest

The authors declared that they have no conflicts of interest to this work.

Author information

Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, 300060, People’s Republic of China

    F. Xu, H. Zhang, Y. Su, J. Kong & B. Qian

  2. Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, People’s Republic of China

    F. Xu, H. Zhang, Y. Su, J. Kong & B. Qian

  3. Epidemiology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI, 96813, USA

    H. Yu

  4. School of Public Health, Shanghai Jiao Tong University, 227 South Chongqing Road, Shanghai, 200025, People’s Republic of China

    B. Qian

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  1. F. Xu
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  2. H. Zhang
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  3. Y. Su
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  4. J. Kong
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Correspondence to B. Qian.

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Xu, F., Zhang, H., Su, Y. et al. Up-regulation of microRNA-183-3p is a potent prognostic marker for lung adenocarcinoma of female non-smokers. Clin Transl Oncol 16, 980–985 (2014). https://doi.org/10.1007/s12094-014-1183-9

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  • DOI: https://doi.org/10.1007/s12094-014-1183-9

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