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CUG-binding protein 1 (CUGBP1) expression and prognosis of non-small cell lung cancer

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Abstract

Background and aims

Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. As CUGBP1 may also play a great role in tumor genesis and deterioration, the purpose of this study was to detect the expression of CUGBP1 mRNA and CUGBP1 and assess the prognostic significance of CUGBP1 in NSCLC.

Methods

Expression of CUGBP1 mRNA and CUGBP was detected by Semi-quantitative PCR and Immunohistochemistry, respectively, from 57 NSCLC patients. The percentage of CUGBP1 mRNA and CUGBP1 expression was correlated with clinical characteristics using χ 2 test. The prognostic significance was assessed by univariate and multivariate analyses in the Cox hazard model.

Results

The expression of CUGBP1 mRNA and CUGBP1 was over-expressed in cancer group and was correlated with TNM stage and Differentiation. By both univariate and multivariate survival analyses, CUGBP1 expression (P = 0.0074, HR = 3.701, 95 % CI 1.420–9.648), TNM-stage (HR = 4.043, 95 % CI 2.098–7.794) and age (HR = 3.207, 95 % CI 1.544–6.664) were noted to be independent indicators of a shorter postsurgical survival.

Conclusions

The expression of CUGBP1 independently predicted a shorter postsurgical survival in NSCLC.

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Acknowledgments

This article was written for a project financed by a grant of Shandong Excellent Young Scientist Research Award Fund Project (BS2010YY013), Shandong Tackle Key Problems in Science and Technology (2010GSF10245). Wenjie Jiao and Ruyong Yao designed the research; Mingzhao Wang and Yongjie Wang carried out the studies; Yiren Luo and Yandong Zhao discussed the results and analyzed data; Jinpeng Zhao wrote the paper. All authors read and approved the final manuscript.

Conflict of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Thoracic Surgery, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, Qingdao, 266003, People’s Republic of China

    W. Jiao, J. Zhao, M. Wang, Y. Wang, Y. Luo, Y. Zhao, D. Tang & Y. Shen

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  1. W. Jiao
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  2. J. Zhao
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  3. M. Wang
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  4. Y. Wang
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  5. Y. Luo
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  6. Y. Zhao
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  8. Y. Shen
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Correspondence to Y. Shen.

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Jiao, W., Zhao, J., Wang, M. et al. CUG-binding protein 1 (CUGBP1) expression and prognosis of non-small cell lung cancer. Clin Transl Oncol 15, 789–795 (2013). https://doi.org/10.1007/s12094-013-1005-5

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  • DOI: https://doi.org/10.1007/s12094-013-1005-5

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