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Next-generation sequencing reveals the secrets of the chronic lymphocytic leukemia genome

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Abstract

The study of the detailed molecular history of cancer development is one of the most promising techniques to understand and fight this diverse and prevalent disease. Unfortunately, this history is as diverse as cancer itself. Therefore, even with next-generation sequencing techniques, it is not easy to distinguish significant (driver) from random (passenger) events. The International Cancer Genome Consortium (ICGC) was formed to solve this fundamental issue by coordinating the sequencing of samples from 50 different cancer types and/or sub-types that are of clinical and societal importance. The contribution of Spain in this consortium has been focused on chronic lymphocytic leukemia (CLL). This approach has unveiled new and unexpected events in the development of CLL. In this review, we introduce the approaches utilized by the consortium for the study of the CLL genome and discuss the recent results and future perspectives of this work.

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Acknowledgments

This work was funded by the Spanish Ministry of Economy and Competitiveness through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII. We are very grateful to all members of the Spanish CLL Genome Consortium for their continuous support and collaboration. We are also very grateful to all patients with CLL who have participated in this study.

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Authors and Affiliations

  1. Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, IUOPA, Universidad de Oviedo, 33006, Oviedo, Spain

    Andrew J. Ramsay, David Rodríguez, Agnieszka Kwarciak & Víctor Quesada

  2. Unidad de Hematopatología, Servicio de Anatomía Patológica, Hospital Clínic, Universitat de Barcelona, IDIBAPS, Barcelona, Spain

    Alejandra Martínez-Trillos & Pedro Jares

Authors
  1. Andrew J. Ramsay
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  2. Alejandra Martínez-Trillos
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  3. Pedro Jares
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  5. Agnieszka Kwarciak
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  6. Víctor Quesada
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Correspondence to Víctor Quesada.

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Ramsay, A.J., Martínez-Trillos, A., Jares, P. et al. Next-generation sequencing reveals the secrets of the chronic lymphocytic leukemia genome. Clin Transl Oncol 15, 3–8 (2013). https://doi.org/10.1007/s12094-012-0922-z

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