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Mesenchymal niches of bone marrow in cancer

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  • Molecular Targets in Oncology
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Abstract

Over the last decade, genetic and cell biology studies have indicated that tumour growth is not only determined by malignant cancer cells themselves, but also by the tumour microenvironment. Cells present in the tumour microenvironment include fibroblasts, vascular, smooth muscle, adipocytes, immune cells and mesenchymal stem cells (MSC). The nature of the relationship between MSC and tumour cells appears dual and whether MSC are proor anti-tumorigenic is a subject of controversial reports. This review is focused on the role of MSC and bone marrow (BM) niches in cancer.

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Authors and Affiliations

  1. Unidad de Biotecnología Celular Área Biología Celular y del Desarrollo, Instituto de Salud Carlos III, Ctra. Majadahonda-Pozuelo, km 2, ES-28220, Majadahonda, Madrid, Spain

    Ander Abarrategi, Luis Mariñas-Pardo, Isabel Mirones, Esther Rincón & Javier García-Castro

  2. Unidad de Investigación Respiratoria Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, A Coruña, Spain

    Luis Mariñas-Pardo

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  1. Ander Abarrategi
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  2. Luis Mariñas-Pardo
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  3. Isabel Mirones
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  4. Esther Rincón
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  5. Javier García-Castro
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Correspondence to Javier García-Castro.

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Abarrategi, A., Mariñas-Pardo, L., Mirones, I. et al. Mesenchymal niches of bone marrow in cancer. Clin Transl Oncol 13, 611–616 (2011). https://doi.org/10.1007/s12094-011-0706-x

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