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Long-term results and prognostic factors of patients with cervical carcinoma treated with concurrent chemoradiotherapy

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Abstract

Aims and background

To evaluate the predictive factors of recurrence in cervical cancer treated with radical radiochemotherapy.

Methods

A retrospective analysis of 56 women was performed. Response was assessed using the RECIST response. Overall survival and disease-free survival curves were estimated by the Kaplan-Meier method and the Cox proportional hazards model was used to analyse predictors of recurrence.

Results

Local recurrence was documented in 16 patients and distant metastases in 15. The Kaplan-Meier survival probabilities were 95.1±6.4% at 3 years and 80.4±13.1% at 5 years and the Kaplan-Meier curve values for disease-free survival were 60.3±14.3% at 3 years and 53.0±15.7% at 5 years. Thirty-five patients were alive and 21 patients died, 19 from metastatic disease and 2 from other causes. Complete response after chemoradiation therapy, squamous cell carcinoma and tumour size ≤4 cm were significantly associated with outcome. In the Cox regression model, tumour size >4 cm (hazard ratio 7.48; 95% CI 2.71–20.6; p<0.001) and partial response (hazard ratio 7.09; 95% CI 2.82–17.8; p<0.001) were predictive factors for disease-free survival and partial response (hazard ratio 3.7; 95% CI 1.3–10.1; p<0.001) and non-squamous cell carcinoma (hazard ratio 3.5; 95% CI 1.2–9.7; p<0.001) were predictive factors for overall survival.

Conclusions

Non-squamous histology and partial response were independent prognostic factors for overall survival and tumour size and partial response were independent prognostic variables for 5-year disease survival.

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Authors and Affiliations

  1. Department of Radiation Oncology, Hospital de l’Esperança, IMAS, C/ Sant Josep de la Muntanya, 12, ES-08024, Barcelona, Spain

    Ana Reig, Ismael Membrive, Palmira Foro, Xavier Sanz, Núria Rodríguez, Joan Lozano, Martí Lacruz, Jaume Quera, Enric Fernández-Velilla & Manuel Algara

  2. Universitat Pompeu Fabra, Barcelona, Spain

    Palmira Foro, Xavier Sanz, Núria Rodríguez, Martí Lacruz, Jaume Quera & Manuel Algara

Authors
  1. Ana Reig
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  2. Ismael Membrive
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  3. Palmira Foro
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  4. Xavier Sanz
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  5. Núria Rodríguez
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  6. Joan Lozano
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  7. Martí Lacruz
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  8. Jaume Quera
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  9. Enric Fernández-Velilla
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  10. Manuel Algara
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Correspondence to Ana Reig.

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Reig, A., Membrive, I., Foro, P. et al. Long-term results and prognostic factors of patients with cervical carcinoma treated with concurrent chemoradiotherapy. Clin Transl Oncol 13, 504–508 (2011). https://doi.org/10.1007/s12094-011-0688-8

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  • DOI: https://doi.org/10.1007/s12094-011-0688-8

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