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Successful treatment of glomus jugulare tumours with gamma knife radiosurgery: clinical and physical aspects of management and review of the literature

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Abstract

Purpose

To demonstrate the feasibility of treatment and early outcomes for patients treated with gamma knife radiosurgery (GKR), with or without surgical resection, for glomus jugulare tumours.

Methods

Between January 2007 and November 2008, 10 patients with glomus jugulare tumours were treated with GKR. Eight had prior surgical resection, seven subtotal resection and one total resection. In two cases GKR was the only definitive therapy. Baseline neurological deficits were prospectively recorded and present in 90% prior to GKR. The median tumour size and volume were 4 cc (0.7–10.9 cc). The median marginal tumour dose was 14 Gy (12–16 Gy). Clinical and radiographic outcomes are reported with a median follow-up of 9.7 months.

Results

Stereotactic frame placement allowed treatment of all 10 lesions, although 3-point fixation was sometimes required to avoid collisions. No patients developed worsening of symptoms or new neurological complaints after GKR; symptom relief was achieved in 50% of cases. No cases of clinical or radiographic progression were identified. Radiographically, 80% of lesions were stable and 20% showed significant shrinkage.

Conclusions

GKR is an excellent option for patients with glomus jugulare tumours after complete or subtotal resection or at recurrence. Appropriately planned frame placement allows successful treatment delivery without difficulty. GKR improved symptoms, prevented neurological progression and achieved radiographic stability or regression in all cases.

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References

  1. Moffat DA, Hardy DG (1989) Surgical management of large glomus jugulare tumors: infra- and trans-temporal approach. J Laryngol Otol 103:1167–1180

    CAS  PubMed  Google Scholar 

  2. Lim M, Gibbs IC, Adler JR Jr et al (2003) The efficacy of linear accelerator stereotactic radiosurgery in treating glomus jugulare tumors. Technol Cancer Res Treat 2:261–265

    PubMed  Google Scholar 

  3. Brewis C, Bottrill ID, Wharton SB et al (2000) Metastases from glomus jugulare tumors. J Laryngol Otol 114:17–23

    CAS  PubMed  Google Scholar 

  4. Green JD Jr, Brackmann DE, Nguyen CD et al (1994) Surgical management of previously untreated glomus jugulare tumors. Laryngoscope 104:917–921

    PubMed  Google Scholar 

  5. Kinney SE (1980) Glomus jugulare tumor surgery with intracranial extension. Otolaryngol Head Neck Surg 88:531–535

    CAS  PubMed  Google Scholar 

  6. Pareschi R, Righini S, Destito D et al (2003) Surgery of glomus jugulare tumors. Skull Base 13:149–157

    Article  PubMed  Google Scholar 

  7. Leroux-Robert J, Ennuyer A (1958) [Malignant tumors of the ear.] Rev Laryngol Otol Rhinol (Bord) 79:117–119

    CAS  Google Scholar 

  8. Springate SC, Weichselbaum RR (1990) Radiation or surgery for chemodectoma of the temporal bone: a review of local control and complications. Head Neck 12:303–307

    Article  CAS  PubMed  Google Scholar 

  9. Mukherji SK, Kasper ME, Tart RP, Mancuso AA (1994) Irradiated paragangliomas of the head and neck: CT and MR appearance. AJNR Am J Neuroradiol 15:357–363

    CAS  PubMed  Google Scholar 

  10. Zabel A, Milker-Zabel S, Huber P et al (2004) Fractionated stereotactic conformal radiotherapy in the management of large chemodectomas of the skull base. Int J Radiat Oncol Biol Phys 58:1445–1450

    Article  PubMed  Google Scholar 

  11. Schwaber MK, Gussack GS, Kirkpatrick W (1988) The role of radiation therapy in the management of catecholamine-secreting glomus tumors. Otolaryngol Head Neck Surg 98:150–154

    CAS  PubMed  Google Scholar 

  12. Liscák R, Vladyka V, Simonová G et al (1998) Leksell gamma knife radiosurgery of the tumor glomus jugulare and tympanicum. Stereotact Funct Neurosurg 70[1 Suppl]:152–160

    Google Scholar 

  13. Liscák R, Vladyka V, Wowra B et al (1999) Gamma Knife radiosurgery of the glomus jugulare tumor: early multicentre experience. Acta Neurochir (Wien) 141:1141–1146

    Article  Google Scholar 

  14. Forest JA III, Jackson CG, MCGrew BM (2001) Long-term control of surgically treated glomus tympanicum tumors. Otol Neurotol 22:232–236

    Article  PubMed  Google Scholar 

  15. Gottfried ON, Liu JK, Coulwell WT (2004) Comparison of radiosurgery and conventional surgery for the treatment of glomus jugulare tumors. Neurosurg Focus 17:E4

    PubMed  Google Scholar 

  16. Hineraman RW, Mendenhall WM, Amdur RJ et al (2001) Definitive radiotherapy in the management of chemodectomas arising in the temporal bone, carotid body, and glomus vagale. Head Neck 23:363–371

    Article  Google Scholar 

  17. Jackson CG, Glasscock ME III, McKennan KX et al (1987) The surgical treatment of skull-base tumors with intracranial extension. Otolaryngol Head Neck Surg 96:175–185

    CAS  PubMed  Google Scholar 

  18. Jackson CG, MCGrew BM, Forest JA et al (2001) Lateral skull base surgery for glomus tumors: long-term control. Otol Neurotol 22:377–382

    Article  CAS  PubMed  Google Scholar 

  19. Sanna M, De Donato G, Piazza P, Falcioni M (2006) Revision glomus tumor surgery. Otolaryngol Clin North Am 39:763–782, vii

    Article  PubMed  Google Scholar 

  20. Patel SJ, Sekhar LN, Cass SP et al (1994) Combined approaches for resection of extensive glomus jugulare tumors. A review of 12 cases. J Neurosurg 80:1026–1038

    Article  CAS  PubMed  Google Scholar 

  21. Watkins LD, Mendoza N, Cheesman AD et al (1994) Glomus jugulare tumours: a review of 61 cases. Acta Neurochir 130:66–70

    Article  CAS  Google Scholar 

  22. Whitfield PC, Grey P, Hardy DG et al (1996) The surgical management of patients with glomus tumours of the skull base. Br J Neurosurg 10:343–350

    Article  CAS  PubMed  Google Scholar 

  23. Al-Mefty O, Teixeira A (2002) Complex tumors of the glomus jugulare: criteria, treatment, and outcome. J Neurosurg 97:1356–1366

    Article  PubMed  Google Scholar 

  24. Jackson CG, Cueva RA, Thedinger BA et al (1991) Cranial nerve preservation in lesions of the jugular fossa. Otolaryngol Head Neck Surg 105:687–693

    CAS  PubMed  Google Scholar 

  25. Jordan JA, Roland PS, McManus C et al (2000) Stereotactic radiosurgery for glomus jugulare tumors. Laryngoscope 110:35–38

    Article  CAS  PubMed  Google Scholar 

  26. Feidenberg SJ, Mendenhall WM, Hinerman RW et al (2002) Radiosurgery for paraganglioma of the temporal bone. Head Neck 24:384–389

    Article  Google Scholar 

  27. Maarouf M, Voges J, Landwehr P et al (2003) Sterotactic linear accelerater-based radiosurgery for the treatment of patients with glomus jugulare tumors. Cancer 97:1093–1098

    Article  PubMed  Google Scholar 

  28. Jang J, Kang YN, Choi BO et al (2006) Evaluation of the accuracy of the CyberKnife. In: Kim SI, Suh TS (eds) World Congress on Medical Physics and Biomedical Engineering 2006, Springer, Berlin, pp 2024–2027

    Google Scholar 

  29. Lim M, Gibbs IC, Adler JR Jr, Chang SD (2004) Efficacy and safety of stereotactic radiosurgery for glomus jugulare tumors. Neurosurg Focus 17:E11

    Article  PubMed  Google Scholar 

  30. Szeifert GT, Kondziolka D, Levivier M, Lunsford LD (eds) (2007) Radiosurgery and pathological fundamentals. Karger, Basel

    Google Scholar 

  31. Foote RL, Coffey RJ, Gorman DA et al (1997) Stereotactic radiosurgery for glomus jugulare tumors: a preliminary report. Int J Radiat Oncol Biol Phys 38:491–495

    CAS  PubMed  Google Scholar 

  32. Eustacchio S, Leber K, Trummer M et al (1999) Gamma knife radiosurgery for glomus jugulare tumours. Acta Neurochir 141:811–818

    Article  CAS  Google Scholar 

  33. Foote RL, Pollock BE, Gorman DA et al (2002) Glomus jugulare tumor: tumor control and complications after stereotactic radiosurgery. Head Neck 24:332–339

    Article  PubMed  Google Scholar 

  34. Saringer W, Khayal H, Ertl A et al (2001) Efficiency of gamma knife radiosurgery in the treatment of glomus jugulare tumors. Minim Invasive Neurosurg 44:141–146

    Article  CAS  PubMed  Google Scholar 

  35. Eustacchio S, Trummer M, Unger F et al (2002) The role of Gamma Knife radiosurgery in the management of glomus jugular tumours. Acta Neurochir Suppl 84:91–97

    CAS  PubMed  Google Scholar 

  36. Sheehan J, Kondziolka D, Flickinger J et al (2005) Gamma knife surgery for glomus yugulare tumors: an intermediate report on efficacy and safety. Journal Neurosur 102[Suppl]:241–246

    Article  Google Scholar 

  37. Pollock BE (2004) Stereotactic RAdiosurgery in patients with glomus jugulare tumors. Neurosurg Focus 17(2):E10

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Radiation Oncology Department, Hospital Duran i Reynals (ICO), Autovía de Castelldefels, km 2.7, ES-08907, Hospitalet de Llobregat, Barcelona, Spain

    Arturo Navarro Martín

  2. Radiation Oncology Department, William Beaumont Hospital, Royal Oak, Michigan, USA

    Ann Maitz, Inga S. Grills & Peter Y. Chen

  3. Otolaryngology Department, William Beaumont Hospital, Royal Oak, Michigan, USA

    Dennis Bojrab, Jack Kartush & Joav Hahn

  4. Neurosurgery Department, William Beaumont Hospital, Royal Oak, Michigan, USA

    Daniel Pieper

Authors
  1. Arturo Navarro Martín
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  2. Ann Maitz
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  3. Inga S. Grills
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  4. Dennis Bojrab
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  8. Daniel Pieper
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Correspondence to Arturo Navarro Martín.

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Navarro Martín, A., Maitz, A., Grills, I.S. et al. Successful treatment of glomus jugulare tumours with gamma knife radiosurgery: clinical and physical aspects of management and review of the literature. Clin Transl Oncol 12, 55–62 (2010). https://doi.org/10.1007/s12094-010-0467-y

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  • DOI: https://doi.org/10.1007/s12094-010-0467-y

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