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Value of the identification of microsatellite instability in colorectal cancer

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Abstract

Objective

Recent studies defend a possible prognostic and therapeutic value of the identification of microsatellite instability (MSI) in colorectal cancer. This work tries to assess the impact that the identification of MSI tumours can have in clinical practice.

Material and methods

We recovered tumour samples from 92 of the 143 patients operated on for colorectal cancer in our institution between 1995 and 2000. Five MSI markers (BAT 25, BAT 26, D2S123, D5S346 and D17S250) were studied on them. The rate and clinicopathologic characteristics of MSI tumours were investigated along with their impact on the global and disease-free survival as compared with microsatellite stable (MSS) tumours.

Results

All 5 microsatellite markers’ status were established in 73 patients (79.3% of the samples). Among them, 7 tumours showed instability in just one marker (low microsatellite instability [MSI-L]) whereas 5 tumours had mutations in 2 or more markers (high microsatellite instability [MSI-H]), for a total 15.4% rate of MSI tumours. All MSI-H tumours were located in the right colon. We could not find any impact from MSI detection on global or disease-free survival.

Conclusions

MSI determination did not identify groups of patients with a different prognosis. Moreover, with such low incidence its determination can only be justified in those cases that fulfill Bethesda’s criteria to identify families with Lynch’s syndrome.

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Authors and Affiliations

  1. General Surgery Department, Fundación Instituto Valenciano de Oncología, C/Prof. Beltrán Báguena, 8-19, ES-46009, Valencia, Spain

    Antonio Barrasa Shaw, Vicente Alapont Olavarrieta, Jorge Campos Máñez & Carlos Vázquez Albaladejo

  2. Molecular Biology Unit, Fundación Instituto Valenciano de Oncología, C/Prof. Beltrán Báguena, 8-19, ES-46009, Valencia, Spain

    José Antonio López-Guerrero & Zaida García-Casado

  3. Pathology Department, Fundación Instituto Valenciano de Oncología, C/Prof. Beltrán Báguena, 8-19, ES-46009, Valencia, Spain

    Ana Calatrava Fons

Authors
  1. Antonio Barrasa Shaw
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  2. José Antonio López-Guerrero
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  3. Ana Calatrava Fons
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  4. Zaida García-Casado
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Correspondence to Antonio Barrasa Shaw.

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Barrasa Shaw, A., López-Guerrero, J.A., Calatrava Fons, A. et al. Value of the identification of microsatellite instability in colorectal cancer. Clin Transl Oncol 11, 465–469 (2009). https://doi.org/10.1007/s12094-009-0386-y

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  • DOI: https://doi.org/10.1007/s12094-009-0386-y

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