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Chemopreventive efficacies of rosiglitazone, fenretinide and their combination against rat mammary carcinogenesis

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Abstract

Introduction

Peroxisome proliferator-activated receptor gamma (PPAR-γ) and retinoic acid receptors (RAR/RXR) belong to the nuclear steroid receptor family. In vitro studies have suggested that PPAR-γ ligands are highly effective in preventing mammary tumours and these effects are enhanced by some retinoids. However, in vivo anti-initiator and anti-promoter efficacies of this combination are not clear.

Aim and methods

The present study aimed to investigate the chemopreventive efficacies of the PPAR-γ ligand rosiglitazone (200 μg/kg/day), synthetic retinoid fenretinide (0.3 mg/kg/day) and their combination on a DMBA-induced rat mammary carcinogenesis model.

Results

In the rosiglitazone group, no malignant tumour developed, apart from the lowest proliferative mammary lesions. In the fenretinide group, 30% developed a malignant tumour but there were no benign tumours. Cancer incidences were 61.5% and 10% in the control and combination groups respectively.

Conclusions

Our results showed that the PPAR-γ ligand rosiglitazone and synthetic retinoid fenretinide have potent chemopreventive properties against in vivo mammary carcinogenesis; however, the efficacies were not enhanced by their combination.

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Authors and Affiliations

  1. Institute of Oncology, Dokuz Eylul University Inciralti, 35340, Izmir, Turkey

    Hilal Kocdor

  2. Department of Surgery School of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey

    Mehmet Ali Kocdor

  3. Department of Pathology School of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey

    Tulay Canda & Duygu Gurel

  4. Department of Medical Oncology School of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey

    Ruksan Cehreli & Mehmet Alakavuklar

  5. Multidisciplinary Laboratory School of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey

    Osman Yilmaz

  6. Department of Biochemistry School of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey

    Gul Guner

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  1. Hilal Kocdor
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  2. Mehmet Ali Kocdor
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  3. Tulay Canda
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Correspondence to Hilal Kocdor.

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Kocdor, H., Kocdor, M.A., Canda, T. et al. Chemopreventive efficacies of rosiglitazone, fenretinide and their combination against rat mammary carcinogenesis. Clin Transl Oncol 11, 243–249 (2009). https://doi.org/10.1007/s12094-009-0347-5

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  • DOI: https://doi.org/10.1007/s12094-009-0347-5

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