Skip to main content

Advertisement

SpringerLink
Log in

Primary neuroendocrine small cell undifferentiated carcinoma of the parotid gland

  • Case Reports
  • Published:
Clinical and Translational Oncology Aims and scope Submit manuscript

Abstract

Neuroendocrine small cell carcinoma is a malignant neoplasm that most frequently arises in the lung. Salivary gland involvement is rare, and the parotid is the main gland affected. We describe the fine-needle aspiration (FNA) cytology findings, the immunophenotypical study and the differential diagnosis of a small cell carcinoma that presented in the parotid of a 91-year-old man. The tumour was treated only with radiotherapy and presented a complete response, with no evidence of the disease after three years of follow-up. This is the first case reported in the literature with good outcome after exclusive irradiation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Koss LG, Spiro RH, Hajdu S (1972) Small cell (oat cell) carcinoma of minor salivary gland origin. Cancer 30:737–741

    Article  PubMed  CAS  Google Scholar 

  2. Gnepp DR, Corio RL, Brannon RB (1986) Small cell carcinoma of the major salivary glands. Cancer 58:705–714

    Article  PubMed  CAS  Google Scholar 

  3. Wang CC (1997) Tumors of the salivary glands. In: Radiation therapy for head and neck neoplasms. Wiley-Liss, Inc., pp 311–326

  4. Henke AC, Cooley ML, Hughes JH, Timmerman TG (2001) Fine-needle aspiration cytology of small-cell carcinoma of the parotid. Diagn Cytopathol 25:126–129

    Article  PubMed  CAS  Google Scholar 

  5. Nagao T, Sugano I, Ishida Y et al (2000) Primary large-cell neuroendocrine carcinoma of the parotid gland: immunohistochemical and molecular analysis of two cases. Mod Pathol 13:554–561

    Article  PubMed  CAS  Google Scholar 

  6. Perez SA, Salazar Fernandez CI, Moreno CJ et al (1998) [Small cell carcinoma of the parotid gland. A case report]. Acta Otorrinolaringol Esp 49:79–82

    Google Scholar 

  7. Vural C, Dogan O, Yavuz E et al (2000) Small cell neuroendocrine carcinoma of the parotid gland. Otolaryngol Head Neck Surg 122:151–152

    Article  PubMed  CAS  Google Scholar 

  8. Cameron WR, Johansson L, Tennvall J (1990) Small cell carcinoma of the parotid. Fine needle aspiration and immunochemical findings in a case. Acta Cytol 34:837–841

    PubMed  CAS  Google Scholar 

  9. Helsel JC, Mrak RE, Hanna E et al (2000) Peripheral primitive neuroectodermal tumor of the parotid gland region: report of a case with fine-needle aspiration findings. Diagn Cytopathol 22:161–166

    Article  PubMed  CAS  Google Scholar 

  10. Nagao T, Gaffey TA, Olsen KD et al (2004) Small cell carcinoma of the major salivary glands: clinicopathologic study with emphasis on cytokeratin 20 immunoreactivity and clinical outcome. Am J Surg Pathol 28:762–770

    Article  PubMed  Google Scholar 

  11. Walker WP, Wittchow RJ, Bottles K et al (1994) Paranuclear blue inclusions in small cell undifferentiated carcinoma: a diagnostically useful finding demonstrated in fine-needle aspiration biopsy smears. Diagn Cytopathol 10:212–215

    Article  PubMed  CAS  Google Scholar 

  12. Brodsky G, Rabson AB (1984) Metastasis to the submandibular gland as the initial presentation of small cell (“oat cell”) lung carcinoma. Oral Surg Oral Med Oral Pathol 58:76–80

    Article  PubMed  CAS  Google Scholar 

  13. Brown DH, Illman J, MacMillan C (1997) Small-cell anaplastic carcinoma of the parotid gland. J Otolaryngol 26:332–334

    PubMed  CAS  Google Scholar 

  14. Marvel JB, Schwartz MR, Donovan DT (1990) Metastatic squamous cell carcinoma of the parotid: a case of an occult primary. Head Neck 12:174–177

    Article  PubMed  CAS  Google Scholar 

  15. Lussier C, Klijanienko J, Vielh P (2000) Fine-needle aspiration of metastatic nonlymphomatous tumors to the major salivary glands: a clinicopathologic study of 40 cases cytologically diagnosed and histologically correlated. Cancer 90:350–356

    Article  PubMed  CAS  Google Scholar 

  16. Zhang C, Cohen JM, Cangiarella JF et al (2000) Fine-needle aspiration of secondary neoplasms involving the salivary glands. A report of 36 cases. Am J Clin Pathol 113:21–28

    Article  PubMed  CAS  Google Scholar 

  17. Chan JK, Suster S, Wenig BM et al (1997) Cytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites. Am J Surg Pathol 21:226–234

    Article  PubMed  CAS  Google Scholar 

  18. Hui KK, Luna MA, Batsakis JG et al (1990) Undifferentiated carcinomas of the major salivary glands. Oral Surg Oral Med Oral Pathol 69:76–83

    Article  PubMed  CAS  Google Scholar 

  19. Pierce ST, Cibull ML, Metcalfe MS, Sloan D (1994) Bone marrow metastases from small cell cancer of the head and neck. Head Neck 16:266–271

    Article  PubMed  CAS  Google Scholar 

  20. Naeem M, Dahiya M, Clark JI et al (2002) Analysis of c-kit protein expression in small-cell lung carcinoma and its implication for prognosis. Hum Pathol 33:1182–1187

    Article  PubMed  CAS  Google Scholar 

  21. Araki K, Ishii G, Yokose T et al (2003) Frequent overexpression of the c-kit protein in large cell neuroendocrine carcinoma of the lung. Lung Cancer 40:173–180

    Article  PubMed  Google Scholar 

  22. Damstrup L, Rygaard K, Spang-Thomsen M, Poulsen HS (1992) Expression of the epidermal growth factor receptor in human small cell lung cancer cell lines. Cancer Res 52:3089–3093

    PubMed  CAS  Google Scholar 

  23. Murray N, Salgia R, Fossella FV (2004) Targeted molecules in small cell lung cancer. Semin Oncol 31:106–111

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Radiation Oncology Department, Hospital Germans Trias i Pujol, Badalona, Spain

    Sandra Jorcano

  2. Pathology Department, Hospital Clínic, Barcelona, Spain

    Adriana Casado & Lluís Colomo

  3. Radiology Department, Hospital Clínic, Barcelona, Spain

    Joan Berenguer

  4. Radiation Oncology Department, Hospital de Reus, Tarragona, Spain

    Meritxell Arenas

  5. Radiation Oncology Department Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain

    Angeles Rovirosa

Authors
  1. Sandra Jorcano
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Adriana Casado
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Joan Berenguer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Meritxell Arenas
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Angeles Rovirosa
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Lluís Colomo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Angeles Rovirosa.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jorcano, S., Casado, A., Berenguer, J. et al. Primary neuroendocrine small cell undifferentiated carcinoma of the parotid gland. Clin Transl Oncol 10, 303–306 (2008). https://doi.org/10.1007/s12094-008-0203-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12094-008-0203-z

Keywords

Search

Navigation