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A multi-cellular molecular signaling and functional network map of C–C motif chemokine ligand 18 (CCL18): a chemokine with immunosuppressive and pro-tumor functions

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Journal of Cell Communication and Signaling Aims and scope

Abstract

The C–C Motif Chemokine Ligand 18 (CCL18) is a beta-chemokine sub-family member with immunomodulatory functions in primates. CCL18-dependent migration and epithelial-to-mesenchymal transition of oral squamous cell carcinoma, squamous cell carcinoma of head and neck, breast cancer, hepatocellular carcinoma, non-small cell lung carcinoma, ovarian cancer, pancreatic ductal carcinoma and bladder cancer cells are well-established. In the tumor niche, tumor-associated macrophages produce CCL18 and its overexpression is correlated with reduced patient survival in multiple cancers. Although multiple receptors including C–C chemokine receptor type 3 (CCR3), type 6 (CCR6), type 8 (CCR8) and G-protein coupled estrogen receptor (GPER1) are reported for CCL18, the Phosphatidylinositol Transfer Protein, Membrane-Associated 3 (PITPNM3) receptor is currently considered as its predominant receptor. Characterization of the molecular events and check points associated with the immunosuppressive and cancer progression support functions induced by CCL18 for their potential towards therapeutic applications is an area of active research. Hence, in this study, we assembled 917 signaling events reported to be induced by CCL18 through their studied receptors in diverse cell types as an integrated knowledgebase for reference, data integration and gene-set enrichment analysis of global transcriptomic and/or proteomics datasets.

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Fig. 1

Data availability

The manually-assembled signaling pathway data is provided in the ‘.xlsx’ format (Supplementary table 1). The pathway data in the ‘.gpml’ format (visualizable through PathVisio tool) with the annotated literature reference to each of the reactions is provided in the Supplementary file 1. This can be exported into multiple formats such as ‘.pdf’, ‘.png’, ‘.jpeg’ formats using the PathVisio tool for enhanced annotation and representation in the future. For the early and efficient incorporation into multiple pathway analysis tools for the enrichment analysis, the pathway data in BioPAX, PSI-MI and also the ‘.gpml’ formats are also made available through WikiPathways (https://www.wikipathways.org/index.php/Pathway:WP5097).

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Acknowledgements

The authors thank Karnataka Biotechnology and Information Technology Services (KBITS), Government of Karnataka, India, for the support to Center for Systems Biology and Molecular Medicine at Yenepoya (Deemed to be University) under the Biotechnology Skill Enhancement Programme in Multiomics Technology (BiSEP GO ITD 02 MDA 2017). Rajesh Raju is a recipient of the Young Scientist Award (YSS/2014/000607) from the Science and Engineering Research Board, Department of Science and Technology (DST), Government of India. Anjana Aravind is a recipient of the Junior Research Fellowship from the Council of Scientific & Industrial Research (CSIR), Government of India. Akhina Palollathil is a recipient of Junior Research Fellowship from the University Grants Commission (UGC), Government of India. D. A. B. Rex is a recipient of Senior Research Fellowship from Indian Council of Medical Research, Government of India.

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  1. Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Karnataka, 575018, Mangalore, India

    Anjana Aravind, Akhina Palollathil, D. A. B. Rex, Thottethodi Subrahmanya Keshava Prasad & Rajesh Raju

  2. Department of Surgical Oncology, Yenepoya Medical College, Yenepoya (Deemed to be University), Karnataka, 575018, Mangalore, India

    Kenkere M. Kiran Kumar , Manavalan Vijayakumar, Rohan Shetty & Jalaluddin Akbar Kandel Codi

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Aravind, A., Palollathil, A., Rex, D.A.B. et al. A multi-cellular molecular signaling and functional network map of C–C motif chemokine ligand 18 (CCL18): a chemokine with immunosuppressive and pro-tumor functions. J. Cell Commun. Signal. 16, 293–300 (2022). https://doi.org/10.1007/s12079-021-00633-3

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