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Small leucine rich proteoglycans in host immunity and renal diseases

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Journal of Cell Communication and Signaling Aims and scope

Abstract

The small leucine rich proteoglycans (SLRPs), structurally consisting of protein cores and various glycosaminoglycan side chains, are grouped into five classes based on common structural and functional properties. Besides being an important structural component of extracellular matrix (ECM), SLRPs have been implicated in the complex network of signal transduction and host immune responses. The focus of this review is on SLRPs in host immunity. Because host immunity plays an important part in the pathogenesis of renal diseases, the role of SLRPs in this set of diseases will also be discussed.

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Abbreviations

SLRP:

Small leucine rich proteoglycans

ECM:

Extracellular matrix

LRR:

Leucine rich repeat

PAMP:

Pathogen associated molecular pattern

DAMP:

Danger associated molecular pattern

HIF-2 α:

Hypoxia-inducible factor 2α

SLE:

Systemic lupus erythematosus

RANTES:

Regulated upon activation, normal T cell expressed and secreted

MyD88:

Myeloid differentiation factor 88

TRIF β:

TIR-domain-containing adaptor-inducing interferon β

TLR:

Toll-like receptor

TNF α:

Tumor necrosis factor α

MIP:

Macrophage inflammatory protein

NLRP3:

NLR family, pyrin domain containing 3

NOX:

NADPH oxidases

ROS:

Reactive oxygen species

TGF:

Transforming growth factor

miR:

Micro-RNA

PDCD:

Programmed cell death protein

MCP-1:

Monocyte chemoattractant protein-1

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Acknowledgements

National Natural Science Foundation of China (grant No.: 81660279, 81701629) , Jiangxi Department of Science and Technology (grant No.: 20151BAB205062 ,20161ACB21016, 20171BCB23088 and 20181ACH80002) and by the startup funding for the scholars studying and coming back from abroad from Ministry of Education, P.R.C (grant No.: 2015060020102070).

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  1. Department of Infectious Diseases, The 1st Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China

    Wei Zou

  2. Department of Gynecology and Obstetrics, The 1st Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

    Junhui Wan, Min Li, Qi Chen, Zhi Zhang & Yi Gong

  3. Department of Burn, The 1st Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

    Juanjuan Xing

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  1. Wei Zou
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Correspondence to Wei Zou.

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Zou, W., Wan, J., Li, M. et al. Small leucine rich proteoglycans in host immunity and renal diseases. J. Cell Commun. Signal. 13, 463–471 (2019). https://doi.org/10.1007/s12079-018-0489-8

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