Abstract
Through analysis of a reported microarray-based high-throughput examination, we found that miR-1275 was significantly down-regulated in nasopharyngeal carcinoma (NPC). While its role and mechanism participated in NPC progression are still little known. Here, we explored the effect of miR-1275 on the progression of NPC. Results demonstrated that miR-1275 was markedly down-regulated in NPC tissues and cell lines. MiR-1275 markedly repressed cell growth as confirmed by CCK8 and colony formation assay, via inhibition of HOXB5 in NPC cell lines. Moreover, miR-1275 suppressed G1/S transition via inhibition of HOXB5. Further, oncogene HOXB5 was evidenced to be a potential target of miR-1275, and its expression was conversely correlated with miR-1275 expression in NPC. Collectively, our study indicated that miR-1275, a tumor suppressor, played a critical effect on NPC progression via inhibition of cell growth, and suppression of G1/S transition by targeting oncogenic HOXB5.
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The Fundamental Research Funds for the Central Universities (No. 2,015,305,020,202) to Cheng-Cao Sun, and The Fund of the Health and Family Planning of Hubei province, China (NO: WJ2015MB036).
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Sun, KY., Peng, T., Chen, Z. et al. MicroRNA-1275 suppresses cell growth, and retards G1/S transition in human nasopharyngeal carcinoma by down-regulation of HOXB5. J. Cell Commun. Signal. 10, 305–314 (2016). https://doi.org/10.1007/s12079-016-0351-9
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DOI: https://doi.org/10.1007/s12079-016-0351-9