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Targeting the jagged/notch pathway: a new treatment for fibrosis?

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Journal of Cell Communication and Signaling Aims and scope

Abstract

There is no treatment for fibrotic disease. TGFβ is known to promote fibrogenesis in vivo and in vitro, however, development of anti-fibrotic strategies targeting the TGFβ axis is problematic owing to the pleitropic nature of TGFβ action. Two recent papers (Kavian et al. 2010; Nyhan et al. 2010) suggest that the jagged/Notch pathway may selectively mediate fibrogenic properties of TGFβ and thus may represent a novel therapeutic approach to fibrosis for scleroderma and kidney fibrosis; these papers are the subject of this commentary.

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Authors and Affiliations

  1. Department of Dentistry, University of Western Ontario, Dental Sciences Building, London, ON, Canada, N6A 5C1

    Andrew Leask

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  1. Andrew Leask
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Correspondence to Andrew Leask.

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Leask, A. Targeting the jagged/notch pathway: a new treatment for fibrosis?. J. Cell Commun. Signal. 4, 197–198 (2010). https://doi.org/10.1007/s12079-010-0101-3

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  • DOI: https://doi.org/10.1007/s12079-010-0101-3

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