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Second primary cancer after liver transplantation in hepatocellular carcinoma: a nationwide population-based study

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Abstract

Purpose

The aim of this study is to evaluate prevalence of second primary cancer (SPC) among hepatocellular carcinoma (HCC) patients after liver transplantation (LT) by using nationwide claims data from South Korea.

Materials and methods

The nationwide cohort included patients who were diagnosed with HCC and received LT from 1 January 2010 to 31 December 2014. We analyzed frequency and standardized incidence ratios (SIRs) to estimate the risk of SPC in HCC patients after LT.

Results

A total of 2462 patients who were diagnosed with HCC and received LT were confirmed. Of these patients, 103 (4.2%) developed SPC after LT; the most common cancer site was lung (16.5%). Patients with HCC receiving LT had high risk of SPC [SIR 2.79, 95% confidence interval (CI) 2.27–3.38], particularly lymphoma (SIR 9.26), myeloma (SIR 10.60), and bladder cancer (SIR 7.19). The 12-, 24-, 36-, and 48-month overall survival for patients with HCC after LT was 92.7, 87.8, 84.6, and 82.1%, respectively.

Conclusions

HCC patients with LT had longer life expectancy and higher risk for SPC compared with the general population. Therefore, close surveillance for SPC is important in patients with HCC receiving LT.

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Authors and Affiliations

  1. Department of Radiation Oncology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Republic of Korea

    Jaesung Heo, O. Kyu Noh, Young-Taek Oh & Mison Chun

  2. Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Korea

    O. Kyu Noh

  3. Office of Biostatistics, Ajou University School of Medicine, Suwon, Korea

    O. Kyu Noh

  4. Health Insurance Review and Assessment Service, Seoul, Korea

    Logyoung Kim

Authors
  1. Jaesung Heo
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  2. O. Kyu Noh
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  3. Young-Taek Oh
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  4. Mison Chun
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  5. Logyoung Kim
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Correspondence to O. Kyu Noh.

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The authors do not have conflicts of interest.

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Heo, J., Noh, O.K., Oh, YT. et al. Second primary cancer after liver transplantation in hepatocellular carcinoma: a nationwide population-based study. Hepatol Int 11, 523–528 (2017). https://doi.org/10.1007/s12072-017-9824-z

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  • DOI: https://doi.org/10.1007/s12072-017-9824-z

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