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Relation Between Posterior Canal Benign Paroxysmal Positional Vertigo and Vitamin D Deficiency

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

The aim of this study is to establish a relationship between vitamin D levels and benign paroxysmal positional vertigo (BPPV) and its recurrence; and to evaluate the remedial effect of vitamin D on BPPV. In a pilot study, 40 patients with clinically diagnosed posterior canal BPPV were evaluated, treated and were followed up for a period of 6 months at ENT Department of Mahatma Gandhi Medical College, Jaipur. All the patients with clinical diagnosis of posterior canal BPPV were tested for 25(OH)D levels at their 1st visit. Patients were divided in two groups after appropriate matching. Group A was given vitamin D supplementation along with canal repositioning manoeuvre (CRM) and group B were only treated by canal repositioning manoeuvre. Patients underwent neuro-otological assessment during follow up visits and recurrent attacks were recorded. This study was conducted on 40 patients with BPPV (26 females and 14 males). The average age was 50 years. Average serum of 25(OH)D at the first visit was (12.2 ng/ml) for group A, and (12.4 ng/ml) for group B, all patients had low serum level of 25(OH)D (below 20 ng/ml). Recurrent BPPV episodes, were significantly lower in group A than that of group B. We second the hypothesis that the patients with BPPV who have insufficient levels of Vitamin D may benefit from vitamin D supplementation and we suggest further epidemiological and pharmacological studies to detect the effect of vitamin D deficiency on development and recurrence of vertigo.

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References

  1. Büki B, Ecker M, Jünger H, Lundberg YW (2012) Vitamin D deficiency and benign paroxysmal positioning vertigo. Published online 2012 Dec 14. https://doi.org/10.1016/j.mehy.2012.11.029

  2. Gu X (2018) Analysis of effect of 1α-hydroxyvitamin D3 on benign paroxysmal positional vertigo and risk factors. Published online 2018 Jan

  3. Sturges M, Canell J (2015) Treating vitamin D deficiency may help reduce the recurrence rate of vertigo, according to study

  4. Talaat HS, Abuhadied G, Talaat AS et al (2015) Low bone mineral density and vitamin D deficiency in patients with benign positional paroxysmal vertigo. Eur Arch Otorhinolaryngol 272(9):2249–2253

    Article  Google Scholar 

  5. Eur Arch Otorinolaryngology. Low bone mineral desity and vit D deficiency in patients with BPPV, 2015

  6. Yamauchi D, Raveendran NN, Pondugula SR et al (2005) Vitamin D upregulates expression of ECaC1 mRNA in semicircular canal. Biochem Biophys Res Commun 331(4):1353–1357

    Article  CAS  Google Scholar 

  7. Yang CJ, Kim Y, Lee HS et al (2017) Bone mineral density and serum 25-hydroxyvitamin D in patients with idiopathic benign paroxysmal positional vertigo. J Vestib Res 27(5–6):287–294

    Google Scholar 

  8. Minasyan A, Keisala T, Zou J, Zhang Y, Toppila E, Syvälä H, Lou YR, Kalueff AV, Pyykkö I, Tuohimaa P, (2009) Vestibular dysfunction in vitamin D receptor mutant mice. J Steroid Biochem Mol Biol 114:161–166

    Article  CAS  Google Scholar 

  9. Gu X, Dong F, Gu J (2018) Analysis of effect of 1α-hydroxyvitamin D3 on benign paroxysmal positional vertigo and risk factors. Exp Ther Med 15(3):2321–2326

    CAS  Google Scholar 

  10. Sanyelbhaa H, Sanyelbhaa A (2015) Vestibular-evoked myogenic potentials and subjective visual vertical testing in patients with vitamin D deficiency/insufficiency. Eur Arch Otorhinolaryngol 272:3233–3239

    Article  Google Scholar 

  11. Yu S, Liu F, Cheng Z, Wang Q (2014) Association between osteoporosis and benign paroxysmal positional vertigo: A systematic review. BMC Neurol 14(1):110

    Article  Google Scholar 

  12. Mohsin FD, Alharbawi FA, Alraho ST (2019) Benign paroxysmal positional vertigo and vitamin D deficiency. Pharma Innov J 8(3):49–52

    CAS  Google Scholar 

  13. Sakaida M, Takeuchi K, Ishinaga H, Adachi M, Majima Y (2003) Long-term outcome of benign paroxysmal positional vertigo. Neurology 60(9):1532–1534

    Article  CAS  Google Scholar 

  14. Brandt T, Huppert D, Hecht J, Karch C, Strupp M (2006) Benign paroxysmal positioning vertigo: a long-term follow-up (6–17 years) of 125 patients. Acta Otolaryngol 126(2):160–163

    Article  Google Scholar 

  15. Rhim GI (2016) Serum vitamin D and recurrent benign paroxysmal positional vertigo. Laryngosc Investig Otolaryngol 1(6):150–153

    Article  Google Scholar 

  16. Rhim LG (2019) Serum vitamin D and long term outcomes of benign paroxysmal positional vertigo. Clin Exp Otorhinolaryngol 12(3):273–278

    Article  CAS  Google Scholar 

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Correspondence to Kanika Sharma.

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Sharma, K., Ojha, T., Dabaria, R. et al. Relation Between Posterior Canal Benign Paroxysmal Positional Vertigo and Vitamin D Deficiency. Indian J Otolaryngol Head Neck Surg 74 (Suppl 3), 4405–4408 (2022). https://doi.org/10.1007/s12070-021-03070-1

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