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Bacterial Biofilms in Chronic Rhinosinusitis and Their Implications for Clinical Management

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

To study the microbiological profile in patients with chronic rhino-sinusitis. To correlate disease severity with the presence of biofilms and host risk factors. To assess outcome of Sinus Surgery 2 weeks post operatively in terms of presence of bacteria and their ability to form biofilm. Prospective study. 50 cases of chronic rhino-sinusitis requiring Functional Endoscopic Sinus Surgery admitted in SDM Hospital, Dharwad, Karnataka were studied using intra-operative mucosal samples for microbiological analysis. The organisms isolated were tested for biofilm forming ability using three in vitro tests. Severity of disease was assessed using SNOT 22 scoring system. Of 50 cases studied, 66% showed presence of chronic rhino-sinusitis with polyposis and had higher SNOT scores compared to those without polyps. Bacterial isolates were obtained from only 17 samples. Staphylococcus species was isolated from 16 samples and Klebsiella pneumoniae from one. 11 Staph spp. isolates showed biofilm forming ability in vitro. Postoperative events in 3 cases yielded biofilm-forming Staphylococcus. Staphylococcus was the most dominant organism isolated and 11 isolates were biofilm formers. Thus the detection of biofilm forming organisms can be considered as a negative prognostic indicator and should forewarn the surgeon about the risk of recurrence.

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Authors and Affiliations

  1. Department of ENT, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, 580009, India

    Abhilasha Karunasagar, Santosh S. Garag & Ashok S. Naik

  2. Department of Microbiology, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, 580009, India

    Suma B. Appannavar & Raghavendra D. Kulkarni

Authors
  1. Abhilasha Karunasagar
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  2. Santosh S. Garag
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  3. Suma B. Appannavar
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  4. Raghavendra D. Kulkarni
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  5. Ashok S. Naik
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Correspondence to Abhilasha Karunasagar.

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Authors declare that they have no conflict of interest. No external funding was used for the study.

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This article does not contain any studies with animals performed by any of the authors.

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Informed consent was obtained from all individual participants included in the study.

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Karunasagar, A., Garag, S.S., Appannavar, S.B. et al. Bacterial Biofilms in Chronic Rhinosinusitis and Their Implications for Clinical Management. Indian J Otolaryngol Head Neck Surg 70, 43–48 (2018). https://doi.org/10.1007/s12070-017-1208-0

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  • DOI: https://doi.org/10.1007/s12070-017-1208-0

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