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Case–control association study of polymorphisms in the angiotensinogen and angiotensin-converting enzyme genes and coronary artery disease and systemic artery hypertension in African-Brazilians and Caucasian-Brazilians

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Abstract

The rennin–angiotensin–aldosterone system (RAAS) is a critical pathway in regulating blood pressure and salt/water homeostasis, possessing an intimate relationship with the development of systemic artery hypertension (SAH). Once hypertension is considered a risk factor for coronary artery disease (CAD), the RAAS is also related to this pathology. This investigation aimed to analyse if the frequencies of AGT M235T (rs699) and ACE I/D (rs4646994) polymorphisms are associated with CAD and SAH in African-Brazilians and Caucasian-Brazilians. In this study we analysed 714 subjects who underwent coronary angiography to detect obstructive lesions and CAD, as well as blood pressure measurement and SAH, grouped according to ethnicity: 266 African-Brazilians and 448 Caucasian-Brazilians. Among CAD and SAH cases and controls, the genotype and allele frequencies of ACE I/D polymorphism were similar in both ethnic groups. The AGT 235TT genotype and 235T allele frequencies were higher in SAH cases (32%, 54.7%) versus controls in Caucasian-Brazilians (19.8%, 46.4%; P= 0.038, P= 0.031, respectively). The AGT 235TT (OR = 1.8; P= 0.028) demonstrated to be an independent factor risk in a multivariate logistic regression increasing SAH risk in Caucasians but not in African-Brazilians. In summary, AGT M235T polymorphism was associated with SAH risk in Caucasian-Brazilians, and no association was detected with CAD. No association was also observed in ACE I/D polymorphism either in CAD or SAH in African-Brazilians and Caucasian-Brazilians.

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Acknowledgements

This study was supported by the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) and by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).

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Authors and Affiliations

  1. Department of Biological Sciences, University of Southwest of Bahia, Campus Jequié, Rua José Moreira Sobrinho, s/n, Jequiezinho, 45200-000, Jequié, Bahia, Brazil

    RICARDO BONFIM-SILVA, LARISSA OLIVEIRA GUIMARÃES, JANDSON SOUZA SANTOS, JAQUELINE FAGUNDES PEREIRA, ANA ANGÉLICA LEAL BARBOSA & DOMINGOS LAZARO SOUZA RIOS

  2. Department of Genetics, Medical School of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, Monte Alegre, 14049-900, Ribeirão Preto, São Paulo, Brazil

    RICARDO BONFIM-SILVA & LARISSA OLIVEIRA GUIMARÃES

  3. Department of Biological Sciences and Health, Federal University of Sergipe, Av. Marechal Rondon, s/n, Jardim Rosa Elze, 49100-000, Aracajú, Sergipe, Brazil

    JANDSON SOUZA SANTOS

  4. Department of Biotechnology, State University of Feira de Santana, Campus Universitário, Avenida Transnordestina, s/n, 44036-900, Feira de Santana, Bahia, Brazil

    JAQUELINE FAGUNDES PEREIRA

  5. Department of Life Sciences, University of the State of Bahia, Campus I, Rua Silveira Martins, 2555, 41195-001, Salvador, Bahia, Brazil

    DOMINGOS LAZARO SOUZA RIOS

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  1. RICARDO BONFIM-SILVA
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[Bonfim-Silva R., Guimarães L. O., Santos J. S., Pereira J. F., Barbosa A. A. L. and Rios D. L. S. 2016 Case–control association study of polymorphisms in the angiotensinogen and angiotensin-converting enzyme genes and coronary artery disease and systemic artery hypertension in African-Brazilians and Caucasian-Brazilians. J. Genet. 95, xx–xx]

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BONFIM-SILVA, R., GUIMARÃES, L.O., SANTOS, J.S. et al. Case–control association study of polymorphisms in the angiotensinogen and angiotensin-converting enzyme genes and coronary artery disease and systemic artery hypertension in African-Brazilians and Caucasian-Brazilians. J Genet 95, 63–69 (2016). https://doi.org/10.1007/s12041-015-0599-5

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