Skip to main content
SpringerLink
Log in

Association between vitamin D receptor gene polymorphism (TaqI) and obesity in Chinese population

  • RESEARCH NOTE
  • Published:
Journal of Genetics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2

References

  • Bai Y., Yu Y., Yu B., Ge J., Ji J., Lu H. et al. 2009 Association of vitamin D receptor polymorphisms with the risk of prostate cancer in the Han population of Southern China. BMC Med. Genet. 10, 125.

  • Bell C. G., Walley A. J. and Froguel P. 2005 The genetics of human obesity. Nat. Rev. Genet. 6, 221–234.

  • Binh T. Q., Nakahori Y., Hien V. T., Khan N. C., Lam N. T., Mai le B. et al. 2011 Correlations between genetic variance and adiposity measures, and gene × gene interactions for obesity in postmenopausal Vietnamese women. J. Genet. 90, 1–9.

  • Bouillon R., Carmeliet G., Lieben L., Watanabe M., Perino A., Auwerx J. et al. 2014 Vitamin D and energy homeostasis of mice and men. Nat. Rev. Endocrinol. 10, 79–87.

  • Ding C., Gao D., Wilding J., Trayhurn P. and Bing C. 2012 Vitamin D signalling in adipose tissue. Br. J. Nutr. 108, 1915–1923.

  • Gu J. M., Xiao W. J., He J. W., Zhang H., Hu W. W., Hu Y. Q. et al. 2009 Association between VDR and ESR1 gene polymorphisms with bone and obesity phenotypes in Chinese male nuclear families. Acta Pharmacol. Sin. 30, 1634– 1642.

  • Haussler M. R., Whitfield G. K., Haussler C. A., Hsieh J. C., Thompson P. D., Selznick S. H. et al. 1998 The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J. Bone Miner. Res. 13, 325–349.

  • He Y. H., Song Y., Liao X. L., Wang L., Li G., Alima et al. 2011 The calcium-sensing receptor affects fat accumulation via effects on antilipolytic pathways in adipose tissue of rats fed low-calcium diets. J. Nutr. 141, 1938–1946.

  • Lementowski P. W. and Zelicof S. B. 2008 Obesity and osteoarthritis. Am. J. Ortho. 37, 148–151.

  • Mishra D. K., Wu Y., Sarkissyan M., Sarkissyan S., Chen Z., Shang X. et al. 2013 Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African–American and Hispanic women. PloS One 8, e57967.

  • Shen J., Goyal A. and Sperling L. 2012 The emerging epidemic of obesity, diabetes, and the metabolic syndrome in China. Cardiol. Res. Pract. 2012, 178675.

  • Uitterlinden A. G., Fang Y., Van Meurs J. B., Pols H. A. and Van Leeuwen J. P. 2004 Genetics and biology of vitamin D receptor polymorphisms. Gene 338, 143–156.

  • Uitterlinden A. G., Fang Y., Van Meurs J. B., Van Leeuwen H. and Pols H. A. 2004 Vitamin D receptor gene polymorphisms in relation to vitamin D related disease states. J. Steroid Biochem. Mol. Biol. 89–90, 187–193.

  • Vasilopoulos Y., Sarafidou T., Kotsa K., Papadimitriou M., Goutzelas Y., Stamatis C. et al. 2013 VDR TaqI is associated with obesity in the Greek population. Gene 512, 237–239.

  • Wang J. H., Keisala T., Solakivi T., Minasyan A., Kalueff A. V. and Tuohimaa P. 2009 Serum cholesterol and expression of ApoAI, LXRbeta and SREBP2 in vitamin D receptor knock-out mice. J. Steroid Biochem. Mol. Biol. 113, 222–226.

  • Wong K. E., Kong J., Zhang W., Szeto F. L., Ye H., Deb D. K. et al. 2011 Targeted expression of human vitamin D receptor in adipocytes decreases energy expenditure and induces obesity in mice. J. Biol. Chem. 286, 33804–33810.

  • Ye W. Z., Reis A. F., Dubois-Laforgue D., Bellanne-Chantelot C., Timsit J. and Velho G. 2001 Vitamin D receptor gene polymorphisms are associated with obesity in type 2 diabetic subjects with early age of onset. Eur. J. Endocrinol. 145, 181– 186.

Download references

Acknowledgements

This work was funded by the National Natural Science Fund of China key project (81130049) and the National 12th Five-Year Scientific and Technical Programme of China (2012BAI02B00).

Author information

Authors and Affiliations

  1. National Key Discipline of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, Heilongjiang, 150000, People’s Republic of China

    HUI-RU FAN, LI-QUN LIN, HAO MA, YING LI & CHANG-HAO SUN

Authors
  1. HUI-RU FAN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. LI-QUN LIN
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. HAO MA
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. YING LI
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. CHANG-HAO SUN
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to CHANG-HAO SUN.

Additional information

[Fan H.-R., Lin L.-Q., Ma H., Li Y. and Sun C.-H. 2015 Association between vitamin D receptor gene polymorphism (TaqI) and obesity in Chinese population. J. Genet. 94, xx–xx]

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

FAN, HR., LIN, LQ., MA, H. et al. Association between vitamin D receptor gene polymorphism (TaqI) and obesity in Chinese population. J Genet 94, 473–478 (2015). https://doi.org/10.1007/s12041-015-0541-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12041-015-0541-x

Keywords

Search

Navigation