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Genetic features of thyroid hormone receptors

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Abstract

Thyroid hormone receptors (TR) are prototypes of nuclear transcription factors that regulate the expression of target genes. These receptors play an important role in many physiological processes. Moreover, a dysfunction of these proteins is often implicated in several human diseases and malignancies. Here we report genetic variations and alterations of the TRs that have been described in the literature as well as their potential role in the development of some human diseases including cancers. The functional effects of some mutations and polymorphisms in TRs on disease susceptibility, especially on cancer risk, are now established. Therefore, further investigations are needed in order to use these receptors as therapeutic targets or as biological markers to decide on appropriate forms of treatment.

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Acknowledgements

This work was supported by the Ministry of Higher Education and Scientific Research in Tunisia.

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  1. Molecular and Cellular Diagnosis Processes, Centre of Biotechnology of Sfax, University of Sfax, Route Sidi Mansour, P. O. Box 1177, 3018, Sfax, Tunisia

    MAHA REBAÏ, IMEN KALLEL & AHMED REBAÏ

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  1. MAHA REBAÏ
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[Rebaï M., Kallel I. and Rebaï A. 2012 Genetic features of thyroid hormone receptors. J. Genet. 91, xx–xx]

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REBAÏ, M., KALLEL, I. & REBAÏ, A. Genetic features of thyroid hormone receptors. J Genet 91, 367–374 (2012). https://doi.org/10.1007/s12041-012-0179-x

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