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Is APOE \(\boldsymbol{\varepsilon}\) 3 a favourable factor for the longevity: an association study in Chinese population

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References

  • Ang L. S., Cruz R. P., Hendel A. and Granville D. J. 2008 Apolipoprotein E, an important player in longevity and age-related diseases. Exp. Gerontol. 43, 615–622.

    Article  PubMed  CAS  Google Scholar 

  • Asada T., Kariya T., Yamagata Z., Kinoshita T. and Asaka A. 1996 Apolipoprotein E allele in centenarians. Neurology 46, 1484.

    Article  PubMed  CAS  Google Scholar 

  • Bennet A. M., Di Angelantonio E., Ye Z., Wensley F., Dahlin A., Ahlbom A. et al. 2007 Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA 298, 1300–1311.

    Article  PubMed  CAS  Google Scholar 

  • Bertram L., McQueen M. B., Mullin K., Blacker D. and Tanzi R. E. 2007 Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat. Genet. 39, 17–23.

    Article  PubMed  CAS  Google Scholar 

  • Choi Y. H., Kim J. H., Kim D. K., Kim J. W., Lee M. S., Kim C. H. et al. 2003 Distributions of ACE and APOE polymorphisms and their relations with dementia status in Korean centenarians. J. Gerontol. (A. Biol. Sci. Med. Sci.) 58, 227–231.

    Article  Google Scholar 

  • Di Rienzo A. and Hudson R. R. 2005 An evolutionary framework for common diseases: the ancestral-susceptibility model. Trends Genet. 21, 596–601.

    Article  PubMed  Google Scholar 

  • Frisoni G. B., Louhija J., Geroldi C. and Trabucchi M. 2001 Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarians Study. J. Gerontol. (A. Biol. Sci. Med. Sci.) 56, 75–78.

    Article  Google Scholar 

  • Hallman D. M., Boerwinkle E., Saha N., Sandholzer C., Menzel H. J., Csazar A. et al. 1991 The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in nine populations. Am. J. Hum. Genet. 49, 338–349.

    PubMed  CAS  Google Scholar 

  • Hixson J. E. and Vernier D. T. 1990 Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J. Lipid Res. 31, 545–548.

    PubMed  CAS  Google Scholar 

  • Jian-Gang Z., Yong-Xing M., Chuan-Fu W., Pei-Fang L., Song-Bai Z., Nui-Fan G. et al. 1998 Apolipoprotein E and longevity among Han Chinese population. Mech. Ageing Dev. 104, 159–167.

    Article  PubMed  CAS  Google Scholar 

  • Louhija J., Viitanen M., Aguero-Torres H. and Tilvis R. 2001 Survival in Finnish centenarians in relation to apolipoprotein E polymorphism. J. Am. Geriatr. Soc. 49, 1007–1008.

    Article  PubMed  CAS  Google Scholar 

  • Pilote L., Dasgupta K., Guru V., Humphries K. H., McGrath J., Norris C. et al. 2007 A comprehensive view of sex-specific issues related to cardiovascular disease. CMAJ 176, S1–44.

    Google Scholar 

  • Rea I. M., Mc Dowell I., McMaster D., Smye M., Stout R. and Evans A. 2001 Apolipoprotein E alleles in nonagenarian subjects in the Belfast Elderly Longitudinal Free-living Ageing Study (BELFAST). Mech. Ageing Dev. 122, 1367–1372.

    Article  PubMed  CAS  Google Scholar 

  • Singh P. P., Singh M. and Mastana S. S. 2006 APOE distribution in world populations with new data from India and the UK. Ann. Hum. Biol. 33, 279–308.

    Article  PubMed  CAS  Google Scholar 

  • Smith J. D. 2002 Apolipoproteins and aging: emerging mechanisms. Ageing Res. Rev. 1, 345–365.

    Article  PubMed  CAS  Google Scholar 

  • Wang X., Wang G., Yang C. and Li X. 2001 Apolipoprotein E gene polymorphism and its association with human longevity in the Uygur nationality in Xinjiang. Chin. Med. J. (Engl) 114, 817–820.

    CAS  Google Scholar 

  • Zunarelli E., Nicoll J. A., Migaldi M. and Trentini G. P. 2000 Apolipoprotein E polymorphism and breast carcinoma: correlation with cell proliferation indices and clinical outcome. Breast Cancer Res. Treat. 63, 193–198.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to ZE YANG.

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Feng J., Xiang L., Wan G., Qi K., Sun L., Huang Z., Zheng C., Lv Z., Hu C. and Yang Z. 2011 Is APOE ε 3 a favourable factor for the longevity: an association study in Chinese population. J. Genet. 90, 343–347

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FENG, J., XIANG, L., WAN, G. et al. Is APOE \(\boldsymbol{\varepsilon}\) 3 a favourable factor for the longevity: an association study in Chinese population. J Genet 90, 343–347 (2011). https://doi.org/10.1007/s12041-011-0075-9

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  • DOI: https://doi.org/10.1007/s12041-011-0075-9

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