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Greener route for intensified synthesis of Tricaprylin using Amberlyst-15

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Abstract

Tricaprylin is a triglyceride of caprylic acid. Tricaprylin is a medium-chain triglyceride. Medium-chain triglycerides are considered as a nutraceutical and have a wide range of application in health foods and nutraceutical industry. In the present study, the synthesis of tricaprylin is investigated using environment-friendly approach i.e., with the application of microwave and heterogeneous catalyst dry acidic Amberlyst-15. The result of various reaction conditions like the molar ratio of reactant, reaction temperature, and catalyst amberlyst loading on the conversion of caprylic acid into tricaprylin is studied. The microwave synthesis is compared with traditional or normal synthesis of tricaprylin. In the present study, it is found that microwave synthesis resulted in a high degree of conversion in less time as compared to conventional synthesis. Conversion of 99.5% is observed in 16 min of reaction between medium-chain fatty acid (C8) and glycerol under optimized reaction parameters of the molar ratio of caprylic acid:glycerol as 3:5 with reaction temperature 800 °C and catalyst loading of 4% (by weight of fatty acid).

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Intensified synthesis of medium-chain triglycerides.

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References

  1. Marten B, Pfeuffer M and Schrezenmeir J 2006 Medium-chain triglycerides Int. Dairy J. 16 1374

    Article  CAS  Google Scholar 

  2. Babayan V K 1987 Medium chain triglycerides and structured lipids Lipids 22 417

    CAS  PubMed  Google Scholar 

  3. Kinsella R, Maher T and Clegg M E 2017 Coconut oil has less satiating properties than medium chain triglyceride oil Physiol. Behav. 179 422

    Article  CAS  Google Scholar 

  4. Kim S M and Rhee J S 1991 Production of medium-chain glycerides by immobilized lipase in a solvent-free system J. Am. Oil Chem. Soc. 68 499

    Article  CAS  Google Scholar 

  5. Lu J, Jin Q, Wang X and Wang X 2017 Preparation of medium and long chain triacylglycerols by lipase-catalyzed interesterification in a solvent-free system Proc. Biochem. 54 89

    Article  CAS  Google Scholar 

  6. Selmi B, Gontier E, Ergan F, Barbotin J N and Thomas D 1997 Lipase-catalyzed synthesis of tricaprylin in a medium solely composed of substrates. Water production and elimination Enzyme Microb. Technol. 20 322

    Article  CAS  Google Scholar 

  7. Pan Q, Yang L and Meng X 2013 Optimization of enzymatic synthesis of tricaprylin in ionic liquids by response surface methodology J. Am. Oil Chem. Soc. 90 501

    Article  CAS  Google Scholar 

  8. Kwon D Y, Song H N and Yoon S H 1996 Synthesis of medium-chain glycerides by lipase in organic solvent J. Am. Oil Chem. Soc. 73 1521

    Article  CAS  Google Scholar 

  9. Wong W C, Basri M, Razak C N A and Salleh A B 2000 Synthesis of medium-chain glycerides using lipase from Candida rugosa J. Am. Oil Chem. Soc. 77 85

    Article  CAS  Google Scholar 

  10. Surat M A, Jauhari S and Desak K R 2012 A brief review: Microwave assisted organic reaction Appl. Sci. Res. 4 645

    Google Scholar 

  11. Perin G, Álvaro G, Westphal E, Viana L H, Jacob R G, Lenardão E J and D’Oca M G M 2008 Transesterification of castor oil assisted by microwave irradiation Fuel 87 2838

    Article  CAS  Google Scholar 

  12. More S B, Gogate P R and Waghmare J S 2017 Intensification of acid catalyzed synthesis of tricaprylin using ultrasound pretreatment Chem. Eng. Process. 120 317

    Article  CAS  Google Scholar 

  13. Deshmane V G, Gogate P R and Pandit A B 2008 Process intensification of synthesis process for medium chain glycerides using cavitation Chem. Eng. J. 145 351

    Article  CAS  Google Scholar 

  14. More S B, Waghmare J S, Gogate P R and Naik S N 2018 Improved synthesis of medium chain triacylglycerol catalyzed by lipase based on use of supercritical carbon dioxide pretreatment Chem. Eng. J. 334 1977

    Article  CAS  Google Scholar 

  15. Mohod A V and Gogate P R 2018 Intensified synthesis of medium chain triglycerides using ultrasonic reactors at a capacity of 4L Ultrason. Sonochem. 42 347

    Article  CAS  Google Scholar 

  16. Boulos Z, Jean D and Christopher P 2013 Method for the preparation of triglycerides of medium chain fatty acids WIPO WO2013126990A1

  17. Sirsam R, Hansora D and Usmani G A 2016 A mini-review on solid acid catalysts for esterification reactions. J. Inst. Eng. (India): Series E 97 167

    CAS  Google Scholar 

  18. Zare M, Golmakani M T and Sardarian A 2020 Green synthesis of banana flavor using different catalysts: a comparative study of different methods Green Chem. Lett. Rev. 13 82

    Article  CAS  Google Scholar 

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Acknowledgements

Harsh Jadhav is thankful to the Department of Science and Technology, Government of India for providing DST-Inspire fellowship for doctoral research.

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Authors and Affiliations

  1. Department of Food Engineering and Technology, Institute of Chemical Technology, Mumbai, Mumbai, Maharashtra, India

    Harsh Jadhav & Uday Annapure

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  1. Harsh Jadhav
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  2. Uday Annapure
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Correspondence to Uday Annapure.

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Jadhav, H., Annapure, U. Greener route for intensified synthesis of Tricaprylin using Amberlyst-15. J Chem Sci 133, 1 (2021). https://doi.org/10.1007/s12039-020-01869-z

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  • DOI: https://doi.org/10.1007/s12039-020-01869-z

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