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Squaric acid: an impressive organocatalyst for the synthesis of biologically relevant 2,3-dihydro-1H-perimidines in water

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Abstract

Squaric acid, a green, metal-free and eco-friendly organocatalyst, has been exploited for the synthesis of biologically interesting 2,3-dihydro-1H-perimidines. The reaction was performed using water as a green reaction medium and the organocatalyst can be easily recovered and reused up to four consecutive cycles without much decrease in catalytic activity. Several advantages of the present methodology are low catalyst loading, excellent catalytic performance, easy catalyst handling, mild reaction conditions, operational simplicity, ease of product isolation, avoidance of column chromatographic separation, a higher yield of the desired product in short reaction time, high atom economy and synthesis of benzophenone based perimidine.

Graphic Abstract

A metal-free, squaric acid-catalyzed methodology was developed for the synthesis of biologically relevant 2, 3-dihydro-1H-perimidines in water.

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Acknowledgements

Authors are thankful to UGC-CAS for the financial grant.

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Authors and Affiliations

  1. Dyestuff Technology Department, Institute of Chemical Technology, N. P. Marg, Matunga, Mumbai, 400 019, Maharashtra, India

    Sushil Khopkar & Ganapati Shankarling

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  1. Sushil Khopkar
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  2. Ganapati Shankarling
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Correspondence to Ganapati Shankarling.

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Khopkar, S., Shankarling, G. Squaric acid: an impressive organocatalyst for the synthesis of biologically relevant 2,3-dihydro-1H-perimidines in water. J Chem Sci 132, 31 (2020). https://doi.org/10.1007/s12039-019-1735-1

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  • DOI: https://doi.org/10.1007/s12039-019-1735-1

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