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Efficient one-pot four-component synthesis of fused thiazolopyridin-2-ones in ionic liquid

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Abstract

An efficient one-pot synthesis of fused thiazolopyridinone derivatives (5-amino-6,7-diphenyl-4,7-dihydro-3H-thiazolo[4,5-b]pyridin-2-ones) by four-component reaction of aldehyde, benzylcyanide, ammonium acetate and thiazolidine-2,4-dione in ionic liquid is reported. This protocol has the advantages of environmental friendliness, higher yields, less reaction time, and convenient operation. Also, optimization of the synthesized compounds has been done using Hyperchem 8.0.

An efficient one-pot synthesis of fused thiazolopyridinone derivatives (5- amino-6,7-diphenyl-4,7-dihydro-3H-thiazolo[4,5-b]pyridin-2-ones) by fourcomponent reaction of aldehyde, benzylcyanide, ammonium acetate and thiazolidine-2,4-dione in ionic liquid is reported. This protocol has the advantages of environmental friendliness, higher yields, less reaction time, and convenient operation.

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Acknowledgements

Authors thank the University Grant Commission (UGC) and the Department of Science and Technology (DST), New Delhi, India.

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Authors and Affiliations

  1. Atma Ram Sanatan Dharma College, University of Delhi, New Delhi, 110 021, India

    PRASHANT SINGH

  2. Department of Applied Chemistry, Babasaheb Bhimrao Ambedkar University, Lucknow, 226 025, India

    PRASHANT SINGH

  3. Department of Chemistry, Motilal Nehru National Institute of Technology, Allahabad, 211 004, India

    KAMLESH KUMARI & GOPAL K MEHROTRA

  4. Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, 226 025, India

    GAURAV KAITHWAS

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  1. PRASHANT SINGH
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SINGH, P., KUMARI, K., KAITHWAS, G. et al. Efficient one-pot four-component synthesis of fused thiazolopyridin-2-ones in ionic liquid. J Chem Sci 125, 1471–1480 (2013). https://doi.org/10.1007/s12039-013-0522-7

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