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The reaction of carbon disulphide with α-haloketones and primary amines in the presence of potassium iodide as catalyst

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Abstract

A simple, mild and convenient method has been developed for the synthesis of 3,4,5-trialkyl-1,3-thiazole-2(3H)-thione derivatives through one pot three-component reaction between a primary amine, carbon disulphide, and α-haloketone in the presence of potassium iodide at room temperature conditions. The products were obtained with excellent yield and appropriate reaction times. This reaction represents a rapid and unprecedented route to the described molecules that have biological specifications.

One-pot three-component reaction of primary amines, carbon disulphide and α-haloketone catalysed by potassium iodide (KI) via a simple, fast, mild and efficient method is reported.

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Acknowledgements

Authors are thankful to the University of Kashan for supporting this work (by Grant NO: 159196/VII).

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, University of Kashan, Kashan, 51167, IR, Iran

    JAVAD SAFAEI-GHOMI & FARIBA SALIMI

  2. Chemistry Department, Zanjan University, P O Box 45195-313, Zanjan, Iran

    ALI RAMAZANI

Authors
  1. JAVAD SAFAEI-GHOMI
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  2. FARIBA SALIMI
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  3. ALI RAMAZANI
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Corresponding author

Correspondence to JAVAD SAFAEI-GHOMI.

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SAFAEI-GHOMI, J., SALIMI, F. & RAMAZANI, A. The reaction of carbon disulphide with α-haloketones and primary amines in the presence of potassium iodide as catalyst. J Chem Sci 125, 1087–1092 (2013). https://doi.org/10.1007/s12039-013-0482-y

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  • DOI: https://doi.org/10.1007/s12039-013-0482-y

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