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A new class of multi-substituted oxazole derivatives: Synthesis and antimicrobial activity

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Abstract

A new and efficient method for the synthesis of multi-substituted oxazole derivatives from various aldehydes has been described. Twenty novel multi-substituted oxazoles containing a heterocyclic moiety were synthesized and evaluated for their antimicrobial activity. The prepared compounds are all reported for the first time and their structures were established by elemental analysis, IR, 1H-NMR, and 13C-NMR and Mass spectra. All the synthesized compounds exhibited in vitro antimicrobial activity.

Twenty novel multi-substituted oxazoles containing a heterocyclic moiety were synthesized and evaluated for their antimicrobial activity. The compounds were characterized by elemental analysis, IR, 1H-NMR, and 13C-NMR and Mass spectra. The compounds exhibited in vitro antimicrobial activity.

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Acknowledgements

The authors are thankful to Sri Krishnadevaraya University for supporting this work.

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Authors and Affiliations

  1. Department of Chemistry, Sri Krishnadevaraya University, Anantapur, 515 055, India

    A BABUL REDDY & G NARAYANA SWAMY

  2. Deptartment of Bio-Chemistry, Sri Krishnadevaraya University, Anantapur, 515 055, India

    R V HYMAVATHI

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  1. A BABUL REDDY
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  2. R V HYMAVATHI
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  3. G NARAYANA SWAMY
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REDDY, A.B., HYMAVATHI, R.V. & SWAMY, G.N. A new class of multi-substituted oxazole derivatives: Synthesis and antimicrobial activity. J Chem Sci 125, 495–509 (2013). https://doi.org/10.1007/s12039-013-0417-7

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