Abstract
An efficient green approach to the synthesis of Schiff bases (11–21) of 1-amino-2-aryl-3-oxo-1,2,4-triazoles (1–3) have been reported under Mg(ClO4)2 as catalyst followed by the reaction with chloroacetyl chloride in solvent-free conditions to yield the azetidinones (22–32) with excellent yields. The synthesized compounds were evaluated for the extent of penetration into biological membranes (clogP), drug-likeliness and finally drug score was calculated and also screened for antitubercular and antimicrobial activities.
An efficient green approach to the synthesis of Schiff bases has been reported using Mg(ClO4)2 as catalyst followed by the reaction with chloroacetyl chloride in solvent-free conditions to yield azetidinone derivatives.
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TAJ, T., KAMBLE, R.R., GIREESH, T. et al. An expeditious green synthesis of Schiff bases and azetidinones derivatised with 1,2,4-triazoles. J Chem Sci 123, 657–666 (2011). https://doi.org/10.1007/s12039-011-0138-8
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DOI: https://doi.org/10.1007/s12039-011-0138-8