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Analysis of nine cases of oral foreign body granuloma related to biomaterials

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Abstract

Foreign bodies can penetrate the interior of soft and, sometimes, hard, tissues in various ways, including through open wounds, lacerations and traumatic accidents. However over the years, evidence of links between the use of dental materials and lately, significant involvement of aesthetic filler materials as foreign bodies in the oral and perioral region have been reported. Foreign body granulomas (FBGs) may develop from this exogenous material, histopathologically characterized by the presence of chronic inflammation and a high amount of macrophages. This study presents nine FBG cases affecting the oral and perioral regions, and carries out a literature review on the main clinical, histopathological and material characteristics used in dental and dermatological procedures related to the appearance of this type of granuloma.

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Authors and Affiliations

  1. Oral Pathology Post-Graduation Program Student, Federal University of Rio Grande do Norte, Natal, RN, Brazil

    Larissa Santos Amaral Rolim, Caio César da Silva Barros & Juliana Campos Pinheiro

  2. Oral Pathology Post-Graduation Program, Dentistry Department, Federal University of Rio Grande do Norte, Natal, RN, Brazil

    Patrícia Teixeira de Oliveira & Lélia Batista de Souza

  3. Oral Pathology Post-Graduation Program, Morphology Department, Federal University of Rio Grande do Norte, Natal, RN, Brazil

    Pedro Paulo de Andrade Santos

Authors
  1. Larissa Santos Amaral Rolim
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  2. Caio César da Silva Barros
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  3. Juliana Campos Pinheiro
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  4. Patrícia Teixeira de Oliveira
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  5. Lélia Batista de Souza
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  6. Pedro Paulo de Andrade Santos
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Corresponding author

Correspondence to Pedro Paulo de Andrade Santos.

Ethics declarations

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was approved by the UFRN Research Ethics Committee, Natal, Brazil (number 1.883.170).

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

Communicated by Rita Mulherkar.

Corresponding editor: Rita Mulherkar

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Rolim, L.S.A., da Silva Barros, C.C., Pinheiro, J.C. et al. Analysis of nine cases of oral foreign body granuloma related to biomaterials. J Biosci 44, 78 (2019). https://doi.org/10.1007/s12038-019-9898-y

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  • DOI: https://doi.org/10.1007/s12038-019-9898-y

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