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Mycobacteria and innate cells: critical encounter for immunogenicity

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Abstract

Protective immunity against mycobacterial infections such as Mycobacterium tuberculosis is mediated by interactions between specific T cells and activated macrophages. To date, many aspects of mycobacterial immunity have shown that innate cells are the key elements that substantially influence the subsequent adaptive host response. During the early phases of infection, phagocytic cells and innate lymphocyte subsets play a pivotal role. Here we summarize the findings of recent investigations on macrophages, dendritic cells and γδ T lymphocytes in the response to mycobacteria.

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Abbreviations

APC:

antigen-presenting cell

ATP:

adenosine triphosphate

BCG:

bacille Calmette-Guérin

DC:

dendritic cell

DOXP:

1-deoxy-d-xylulose-5phosphate

GM-CSF:

granulocyte-macrophage colony-stimulating factor

IFN:

interferon

IL:

interleukin

imDC:

immature dendritic cell

LAM:

lipoarabinomannan

LPS:

lipopolysaccharide

MDM:

monocyte-derived macrophage

MHC:

major histocompatibility complex

MTB:

Mycobacterium tuberculosis

MVA:

mevalonate

Th:

T-helper

TLR:

toll-like receptors

TNF:

tumour necrosis factor

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  1. Unit of Cellular Immunology “Fabrizio Poccia”, National Institute for Infectious Diseases “Lazzaro Spallanzani”, IRCCS-Rome, Italy

    Angelo Martino

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Correspondence to Angelo Martino.

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Martino, A. Mycobacteria and innate cells: critical encounter for immunogenicity. J Biosci 33, 137–144 (2008). https://doi.org/10.1007/s12038-008-0029-4

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  • DOI: https://doi.org/10.1007/s12038-008-0029-4

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