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Mechanisms of HSP72 release

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Abstract

Currently two mechanisms are recognized by which heat shock proteins (HSP) are released from cells; a passive release mechanism, including necrotic cell death, severe blunt trauma, surgery and following infection with lytic viruses, and an active release mechanism which involves the non classical protein release pathway. HSPs are released both as free HSP and within exosomes. This review covers recent findings on the mechanism by which stress induces the release of HSP72 into the circulation and the biological significance of circulating HSP72 to host defense against disease.

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Abbreviations

APC:

antigen presenting cells

eHSP72:

extracellular HSP72

Hsc73:

constitutive seventy-kilo Dalton heat shock protein

HSP72:

inducible seventy-kilo Dalton heat shock protein

IFN-γ:

interferon-gamma

iHSP72:

intracellular HSP72

TLR:

toll-like receptors

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  1. Division of Investigative Pathology, Scott & White Clinic and Texas A&M University System Health Science Center College of Medicine, 2401 South 31st Street, Temple, TX, 76508, USA

    Alexzander Asea

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Asea, A. Mechanisms of HSP72 release. J Biosci 32, 579–584 (2007). https://doi.org/10.1007/s12038-007-0057-5

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