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Cognitive Control Processes and Functional Cerebral Asymmetries: Association with Variation in the Handedness-Associated Gene LRRTM1

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Abstract

Cognitive control processes play an essential role not only in controlling actions but also in guiding attentional selection processes. Interestingly, these processes are strongly affected by organizational principles of the cerebral cortex and related functional asymmetries, but the neurobiological foundations are elusive. We ask whether neurobiological mechanisms that affect functional cerebral asymmetries will also modulate effects of top-down control processes on functional cerebral asymmetries. To this end, we examined potential effects of the imprinted gene leucine-rich repeat transmembrane neuronal 1 (LRRTM1) on attentional biasing processes in a forced attention dichotic listening task in 983 healthy adult participants of Caucasian descent using the “iDichotic smartphone app.” The results show that functional cerebral asymmetries in the language domain are associated with the rs6733871 LRRTM1 polymorphism when cognitive control and top-down attentional mechanisms modulate processes in bottom-up attentional selection processes that are dependent on functional cerebral asymmetries. There is no evidence for an effect of LRRTM1 on functional cerebral asymmetries in the language domain unrelated to cognitive control processes. The results suggest that cognitive control processes are an important factor to consider when being interested in the molecular genetic basis of functional cerebral architecture.

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Acknowledgements

This work was funded by grants from the Deutsche Forschungsgemeinschaft (DFG) Gu227/16-1 and BE4045/26-1.

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Authors and Affiliations

  1. Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Schubertstrasse 42, 01309, Dresden, Germany

    Christian Beste

  2. Experimental Neurobiology, National Institute of Mental Health, Klecany, Czech Republic

    Christian Beste

  3. Department of Human Genetics, Ruhr-University Bochum, Bochum, Germany

    Larissa Arning, Wanda M. Gerding & Jörg T. Epplen

  4. Institute of Cognitive Neuroscience, Biopsychology, Department of Psychology, Ruhr-University Bochum, Bochum, Germany

    Alexandra Mertins, Melanie C. Röder, Onur Güntürkün & Sebastian Ocklenburg

  5. Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway

    Josef J. Bless & Kenneth Hugdahl

  6. NORMENT Center of Excellence, University of Oslo, Oslo, Norway

    Kenneth Hugdahl

  7. Department of Psychology, University of Oslo, Oslo, Norway

    René Westerhausen

  8. Department of Psychiatry, Haukekland University Hospital, Bergen, Norway

    Kenneth Hugdahl

Authors
  1. Christian Beste
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  2. Larissa Arning
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  3. Wanda M. Gerding
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  7. Josef J. Bless
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  10. Onur Güntürkün
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  11. Sebastian Ocklenburg
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Corresponding author

Correspondence to Christian Beste.

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The study was approved by the ethics committee of the medical faculty, Ruhr-University Bochum. All participants gave written informed consent and were treated in accordance with the declaration of Helsinki.

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The authors declare that they have no conflict of interest.

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Beste, C., Arning, L., Gerding, W.M. et al. Cognitive Control Processes and Functional Cerebral Asymmetries: Association with Variation in the Handedness-Associated Gene LRRTM1 . Mol Neurobiol 55, 2268–2274 (2018). https://doi.org/10.1007/s12035-017-0485-7

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  • DOI: https://doi.org/10.1007/s12035-017-0485-7

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