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Transitional Progenitors during Vertebrate Retinogenesis

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An Erratum to this article was published on 08 August 2016

Abstract

The retina is a delicate neural tissue responsible for light signal capturing, modulating, and passing to mid-brain. The brain then translated the signals into three-dimensional vision. The mature retina is composed of more than 50 subtypes of cells, all of which are developed from a pool of early multipotent retinal progenitors, which pass through sequential statuses of oligopotent, bipotent, and unipotent progenitors, and finally become terminally differentiated retinal cells. A transitional progenitor model is proposed here to describe how intrinsic developmental programs, along with environmental cues, control the step-by-step differentiation during retinogenesis. The model could elegantly explain many current findings as well as predict roles of intrinsic factors during retinal development.

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Acknowledgments

The author thanks Drs. Courtni Newsome, Min Zou, Shengguo Li, and Rashade A. H. Haynes II for critical readings and helpful comments on the manuscript. The author apologizes that so many great works in the field are not cited due to space limit and accessibility of full articles. This work is partially supported by funding from the Zhongshan Ophthalmic Center.

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  1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 South Xianlie Road, Guangzhou, Gongdong, 510060, China

    Kangxin Jin

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An erratum to this article is available at http://dx.doi.org/10.1007/s12035-016-0037-6.

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Jin, K. Transitional Progenitors during Vertebrate Retinogenesis. Mol Neurobiol 54, 3565–3576 (2017). https://doi.org/10.1007/s12035-016-9899-x

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