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The Physiology of BDNF and Its Relationship with ADHD

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Abstract

Brain-derived neurotrophic factor (BDNF) is a major neurotrophin in the central nervous system that plays a critical role in the physiological brain functions via its two independent receptors: tropomyosin-related kinase B (TrkB) and p75, especially in the neurodevelopment. Disrupting of BDNF and its downstream signals has been found in many neuropsychological diseases, including attention-deficit hyperactivity disorder (ADHD), a common mental disorder which is prevalent in childhood. Understanding the physiological functions of BDNF during neural development and its potential relationship with ADHD will help us to elucidate the possible mechanisms of ADHD and to develop therapeutic approaches for this disease. In this review, we summarized the important literatures for the physiological functions of BDNF in the neurodevelopment. We also performed an association study on the functional genetic variation of BDNF and ADHD by a case-control study in the Chinese mainland population and revealed the potential correlation between BDNF and ADHD which needs further research to confirm.

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Acknowledgments

This work was supported in part by the National Natural Science Foundation of China (81361120245, 81101016), MOST International Collaboration Grant (2011DFG33250), New Century Education Talent (NCET-10-0421) to Dr. Ling-Qiang Zhu, and Program for Changjiang Scholars and Innovative Research Team in University (IRT13016) to Dr. Jian-Guo Chen.

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The authors declare that there are no conflicts of interest.

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Authors and Affiliations

  1. Department of Pathophysiology, School of Basic Medicine, Institute of Brain Research, Sino-Canada Collaborative Platform on Molecular Biology of Neurological Disease, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China

    De-Yi Liu, Ou-Yang Guo & Ling-Qiang Zhu

  2. Key Laboratory of Environment and Health, Ministry of Education & Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China

    Xue-Mei Shen, Fang-Fen Yuan & Jing Wu

  3. Department of Child Health Care, Hunan Children’s Hospital, Changsha, 410007, People’s Republic of China

    Yan Zhong

  4. Department of Pharmacology, School of Basic Medicine, Institute of Brain Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China

    Jian-Guo Chen

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  1. De-Yi Liu
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Correspondence to Ling-Qiang Zhu or Jing Wu.

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Liu, DY., Shen, XM., Yuan, FF. et al. The Physiology of BDNF and Its Relationship with ADHD. Mol Neurobiol 52, 1467–1476 (2015). https://doi.org/10.1007/s12035-014-8956-6

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