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Bisphenol-A Impairs Myelination Potential During Development in the Hippocampus of the Rat Brain

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A Correction to this article was published on 03 May 2019

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Abstract

Myelin is the functional implication of oligodendrocytes (OLs), which is involved in insulation of axons and promoting rapid propagation of action potential in the brain. OLs are derived from oligodendrocyte progenitor cells (OPCs), which proliferate, differentiate, and migrate throughout the central nervous system. Defects in myelination process lead to the onset of several neurological and neurodegenerative disorders. Exposure to synthetic xenoestrogen bisphenol-A (BPA) causes cognitive dysfunction, impairs hippocampal neurogenesis, and causes onset of neurodevelopmental disorders. However, the effects of BPA on OPC proliferation, differentiation and myelination, and associated cellular and molecular mechanism(s) in the hippocampus of the rat brain are still largely unknown. We found that BPA significantly decreased bromodeoxyuridine (BrdU)-positive cell proliferation and number and size of oligospheres. We observed reduced co-localization of BrdU with myelination markers CNPase and platelet-derived growth factor receptor-α (PDGFR-α), suggesting impaired proliferation and differentiation of OPCs by BPA in culture. We studied the effects of BPA exposure during prenatal and postnatal periods on cellular and molecular alteration(s) in the myelination process in the hippocampus region of the rat brain at postnatal day 21 and 90. BPA exposure both in vitro and in vivo altered proliferation and differentiation potential of OPCs and decreased the expression of genes and levels of proteins that are involved in myelination. Ultrastructural electron microscopy analysis revealed that BPA exposure caused decompaction of myelinated axons and altered g-ratio at both the developmental periods as compared to control. These results suggest that BPA exposure both during prenatal and postnatal periods alters myelination in the hippocampus of the rat brain leading to cognitive deficits.

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Change history

  • 03 May 2019

    The original version of this article unfortunately contained a mistake. The authors regret that inadvertent errors were observed in Figure 2E and Figure 10 B&D. The corrected representative images are now incorporated. These corrections does not change the conclusions and text of the article.

  • 03 May 2019

    The original version of this article unfortunately contained a mistake. The authors regret that inadvertent errors were observed in Figure 2E and Figure 10 B&D. The corrected representative images are now incorporated. These corrections does not change the conclusions and text of the article.

  • 03 May 2019

    The original version of this article unfortunately contained a mistake. The authors regret that inadvertent errors were observed in Figure 2E and Figure 10 B&D. The corrected representative images are now incorporated. These corrections does not change the conclusions and text of the article.

  • 03 May 2019

    The original version of this article unfortunately contained a mistake. The authors regret that inadvertent errors were observed in Figure 2E and Figure 10 B&D. The corrected representative images are now incorporated. These corrections does not change the conclusions and text of the article.

Abbreviations

BPA:

Bisphenol-A

NPCs:

Neural progenitor cells

PND:

Postnatal day

GD:

Gestational day

NSCs:

Neural stem cells

OPCs:

Oligodendrocyte progenitor cells

TEM:

Transmission electron microscopy

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Acknowledgments

This work was supported by the Indian Council of Medical Research (ICMR) project grant GAP-244 to R.K.C. S.K.T. and S.A. are recipients of a Senior Research Fellowship from University Grants Commission and Council of Scientific and Industrial Research, New Delhi, respectively. CSIR-IITR Manuscript Communication Number is 3228.

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The authors declare no competing financial interest.

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Authors and Affiliations

  1. Developmental Toxicology Division, Systems Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), 80 MG Marg, Lucknow, UP, 226001, India

    Shashi Kant Tiwari, Swati Agarwal, Lalit Kumar Singh Chauhan & Rajnish Kumar Chaturvedi

  2. Academy of Scientific and Innovative Research (AcSIR), New Delhi, India

    Shashi Kant Tiwari, Swati Agarwal & Rajnish Kumar Chaturvedi

  3. Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India

    Vijay Nath Mishra

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  1. Shashi Kant Tiwari
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Correspondence to Rajnish Kumar Chaturvedi.

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Shashi Kant Tiwari and Swati Agarwal contributed equally to this work.

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Tiwari, S.K., Agarwal, S., Chauhan, L.K.S. et al. Bisphenol-A Impairs Myelination Potential During Development in the Hippocampus of the Rat Brain. Mol Neurobiol 51, 1395–1416 (2015). https://doi.org/10.1007/s12035-014-8817-3

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